Phytoestrogens and Mycoestrogens Induce Signature Structure Dynamics Changes on Estrogen Receptor ?

Xueyan Chen, Ugur Uzuner, Man Li, Weibing Shi, Joshua S. Yuan and Susie Y. Dai
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Xueyan Chen: Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA
Ugur Uzuner: Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843, USA
Man Li: Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843, USA
Weibing Shi: Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843, USA
Joshua S. Yuan: Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843, USA
Susie Y. Dai: Department of Veterinary Pathology, Texas A&M University, College Station, TX 77843, USA

IJERPH, 2016, vol. 13, issue 9, 1-14

Abstract: Endocrine disrupters include a broad spectrum of chemicals such as industrial chemicals, natural estrogens and androgens, synthetic estrogens and androgens. Phytoestrogens are widely present in diet and food supplements; mycoestrogens are frequently found in grains. As human beings and animals are commonly exposed to phytoestrogens and mycoestrogens in diet and environment, it is important to understand the potential beneficial or hazardous effects of estrogenic compounds. Many bioassays have been established to study the binding of estrogenic compounds with estrogen receptor (ER) and provided rich data in the literature. However, limited assays can offer structure information with regard to the ligand/ER complex. Our current study surveys the global structure dynamics changes for ER? ligand binding domain (LBD) when phytoestrogens and mycoestrogens bind. The assay is based on the structure dynamics information probed by hydrogen deuterium exchange mass spectrometry and offers a unique viewpoint to elucidate the mechanism how phytoestrogens and mycoestrogens interact with estrogen receptor. The cluster analysis based on the hydrogen deuterium exchange (HDX) assay data reveals a unique pattern when phytoestrogens and mycoestrogens bind with ER? LBD compared to that of estradiol and synthetic estrogen modulators. Our study highlights that structure dynamics could play an important role in the structure function relationship when endocrine disrupters interact with estrogen receptors.

Keywords: estrogen receptor; phytoestrogen; mycoestrogen; structure dynamics; mass spectrometry (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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