Associations of Cholesteryl Ester Transfer Protein TaqIB Polymorphism with the Composite Ischemic Cardiovascular Disease Risk and HDL-C Concentrations: A Meta-Analysis

Shu-xia Guo, Ming-hong Yao, Yu-song Ding, Jing-yu Zhang, Yi-zhong Yan, Jia-ming Liu, Mei Zhang, Dong-sheng Rui, Qiang Niu, Jia He, Heng Guo and Ru-lin Ma
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Shu-xia Guo: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Ming-hong Yao: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Yu-song Ding: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Jing-yu Zhang: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Yi-zhong Yan: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Jia-ming Liu: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Mei Zhang: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Dong-sheng Rui: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Qiang Niu: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Jia He: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Heng Guo: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China
Ru-lin Ma: Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi 832000, Xinjiang Uyghur Autonomous Region, China

IJERPH, 2016, vol. 13, issue 9, 1-19

Abstract: Background : Previous studies have evaluated the associations between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism (rs708272), the risk of developing composite ischemic cardiovascular disease (CVD) and the concentration of high-density lipoprotein cholesterol (HDL-C), but results remain controversial. The objective of this study was to investigate whether a relationship exists between these factors. Methods : We conducted a meta-analysis of available studies to clarify the associations of the CETP TaqIB polymorphism with HDL-C concentration and the composite ischemic CVD risk in both Asians and Caucasians. All statistical analyses were done with Stata 12.0. Results : Through utilization of the Cochrane Library, Embase, PubMed, Web of Science, Springer, China Science and Technology Journal Database, China National Knowledge Infrastructure, Google Scholar, and Baidu Library, a total of 45 studies from 44 papers with 20,866 cases and 21,298 controls were combined showing a significant association between the CETP TaqIB variant and composite ischemic CVD risk. Carriers of allele TaqIB-B1 were found to have a higher risk of composite ischemic CVD than non-carriers: OR = 1.15, 95% CI = 1.09–1.21, p < 0.001. Meanwhile, 28 studies with 23,959 subjects were included in the association between the CETP TaqIB polymorphism and the concentration of HDL-C. Results suggested that carriers of the B1B1 genotype had lower concentrations of HDL-C than those of the B2B2 genotype: SMD = 0.50, 95% CI = 0.36–0.65, p < 0.001. Conclusions : The synthesis of available evidence demonstrates that the CETP TaqIB polymorphism protects against composite ischemic CVD risk and is associated with a higher HDL-C concentration in both Asians and Caucasians.

Keywords: cholesteryl ester transfer protein; polymorphism; composite ischemic cardiovascular disease; HDL-C; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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