Role of Deficient Mismatch Repair in the Personalized Management of Colorectal Cancer

Cong-Min Zhang, Jin-Feng Lv, Liang Gong, Lin-Yu Yu, Xiao-Ping Chen, Hong-Hao Zhou and Lan Fan
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Cong-Min Zhang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Jin-Feng Lv: Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China
Liang Gong: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Lin-Yu Yu: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Xiao-Ping Chen: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Hong-Hao Zhou: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Lan Fan: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China

IJERPH, 2016, vol. 13, issue 9, 1-17

Abstract: Colorectal cancer (CRC) represents the third most common type of cancer in developed countries and one of the leading causes of cancer deaths worldwide. Personalized management of CRC has gained increasing attention since there are large inter-individual variations in the prognosis and response to drugs used to treat CRC owing to molecular heterogeneity. Approximately 15% of CRCs are caused by deficient mismatch repair (dMMR) characterized by microsatellite instability (MSI) phenotype. The present review is aimed at highlighting the role of MMR status in informing prognosis and personalized treatment of CRC including adjuvant chemotherapy, targeted therapy, and immune checkpoint inhibitor therapy to guide the individualized therapy of CRC.

Keywords: colorectal cancer; personalized treatment; mismatch repair system; microsatellite instability; adjuvant chemotherapy; targeted therapy; immune checkpoint inhibitor therapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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