Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome

Wei Zhou, Fang Fang, Wenting Zhu, Zi-Jiang Chen, Yanzhi Du and Jun Zhang
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Wei Zhou: Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China
Fang Fang: Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China
Wenting Zhu: Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China
Zi-Jiang Chen: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong 250100, China
Yanzhi Du: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China
Jun Zhang: Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200092, China

IJERPH, 2016, vol. 14, issue 1, 1-7

Abstract: To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (? = ?0.34, 95% CI = ?0.60, ?0.08; p = 0.01). Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. No association was observed between BPA and INHB. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve.

Keywords: bisphenol A; ovarian reserve; antral follicle count; antimullerian hormone; day-3 follicle stimulating hormone (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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