Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring

Elodie Haraux, Karine Braun, Philippe Buisson, Erwan Stéphan-Blanchard, Camille Devauchelle, Jannick Ricard, Bernard Boudailliez, Pierre Tourneux, Richard Gouron and Karen Chardon
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Elodie Haraux: Department of Paediatric Surgery, Amiens University Hospital, 80054 Amiens, France
Karine Braun: Department of Paediatrics, Amiens University Hospital, 80054 Amiens, France
Philippe Buisson: Department of Paediatric Surgery, Amiens University Hospital, 80054 Amiens, France
Erwan Stéphan-Blanchard: PériTox-INERIS Laboratory, Jules Verne University of Picardy, 80054 Amiens, France
Camille Devauchelle: Department of Paediatrics, Creil Hospital, 60100 Creil, France
Jannick Ricard: Department of Paediatric Surgery, Amiens University Hospital, 80054 Amiens, France
Bernard Boudailliez: Department of Paediatrics, Amiens University Hospital, 80054 Amiens, France
Pierre Tourneux: Department of Paediatric Intensive Care Unit, Amiens University Hospital, 80054 Amiens, France
Richard Gouron: Department of Paediatric Surgery, Amiens University Hospital, 80054 Amiens, France
Karen Chardon: PériTox-INERIS Laboratory, Jules Verne University of Picardy, 80054 Amiens, France

IJERPH, 2016, vol. 14, issue 1, 1-14

Abstract: Pregnant women are exposed to various chemical products at home and at work. Some of these products contain endocrine-disrupting chemicals (EDCs) such as cosmetics, pesticides, industrial chemicals, heavy metals, plastics or medications that could alter sexual differentiation and increase the risk of hypospadias. We evaluated maternal occupational and household exposures that could constitute risk factors for hypospadias. From 2011 to 2014, we enrolled 57 full-term newborns with hypospadias and three randomly selected controls per case (162 control newborns), matched for gestational age, from 11 maternity units in Picardy, France. Neonatal and parental data were collected at birth (personal characteristics, maternal lifestyle, and medical history). Maternal occupational exposure was assessed by a job-exposure matrix for EDCs from a job history questionnaire completed by mothers. Odds ratios (OR) and 95% confidence intervals (CI) were calculated with univariate and multivariable logistic regression, and adjusted for relevant covariates. Multivariate analysis showed a strong association between hypospadias and potential maternal occupational exposure to EDCs and maternal household use of hair cosmetics (OR 6.1, 95% CI: 1.1–34.9; OR: 9.6, 95% CI: 1.4–66.1, respectively). Our results suggest that maternal occupational exposure to EDCs is a risk factor for hypospadias and suggests a possible influence of household use of hair cosmetics during early pregnancy on the incidence of hypospadias in the offspring. A larger study with more accurate exposure assessment should evaluate the impact of EDCs in hair cosmetics on the incidence of hypospadias.

Keywords: hypospadias; risk factor; endocrine-disrupting chemicals; cosmetics (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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