Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population

Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun, Wei Gong, Qiaoyun Zhang, Baoli Zhu and Yan An
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Hengdong Zhang: Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China
Ming Xu: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China
Qiuni Zhao: School of Public Health, Southeast University, Nanjing 210009, China
Kai Sun: Department of Emergency Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China
Wei Gong: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China
Qiaoyun Zhang: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China
Baoli Zhu: Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, China
Yan An: Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, No. 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China

IJERPH, 2016, vol. 14, issue 1, 1-8

Abstract: Lead ( Pb ) is one of the major contaminants in many industries, and imposes hazardous effects on multiple human organs and systems. Studies have shown that lead is able to induce the alteration of microRNA (miRNA) expression in serum and organs. In this study we investigated whether polymorphisms in miRNA-regulating genes were associated with the risk of lead exposure. We genotyped seven single-nucleotide polymorphisms (SNPs) in 113 lead-sensitive and 113 lead-resistant lead-related Chinese workers by Taqman analysis. The lead-sensitive group showed a significantly higher blood lead level (BLL) than the resistant group based on unconditional logistic regression results. One SNP in XPO5 extron (rs2257082) was significantly associated with lead-poisoning ( p = 0.022, odds rate (OR) = 1.63, 95% confidence interval (CI) = 1.07–2.47 in the C allele compared to the T allele). There were no significant associations between the other six SNPs and the blood lead levels. Therefore, polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations, and to develop more specific and accurate preventions.

Keywords: lead-sensitive and resistant; blood leads level; XPO5 polymorphism; miRNA regulation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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