Endocrine Disruptors Leading to Obesity and Related Diseases

Demetrios Petrakis, Loukia Vassilopoulou, Charalampos Mamoulakis, Christos Psycharakis, Aliki Anifantaki, Stavros Sifakis, Anca Oana Docea, John Tsiaoussis, Antonios Makrigiannakis and Aristides M. Tsatsakis
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Demetrios Petrakis: Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece
Loukia Vassilopoulou: Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece
Charalampos Mamoulakis: Department of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece
Christos Psycharakis: Department of Obstetrics and Gynecology, Venizeleio—Pananio General Hospital of Heraklion, 71409 Heraklion, Crete, Greece
Aliki Anifantaki: Crete Fertility Center, 56, Arch. Makariou & Sof. Venizelou Str., 71202 Heraklion, Crete, Greece
Stavros Sifakis: Mitera Hospital, 71409 Heraklion, Crete, Greece
Anca Oana Docea: Department of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Petru Rares, 200349 Craiova, Romania
John Tsiaoussis: Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece
Antonios Makrigiannakis: Department of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece
Aristides M. Tsatsakis: Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece

IJERPH, 2017, vol. 14, issue 10, 1-18

Abstract: The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

Keywords: cardiovascular diseases; carcinogenesis; diabetes mellitus; endocrine disruptors; infertility; metabolic syndrome; obesity; pesticides (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (5)

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