Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults

Ikenna C. Eze, Medea Imboden, Maria Foraster, Emmanuel Schaffner, Ashish Kumar, Danielle Vienneau, Harris Héritier, Franziska Rudzik, Laurie Thiesse, Reto Pieren, Arnold Von Eckardstein, Christian Schindler, Mark Brink, Jean-Marc Wunderli, Christian Cajochen, Martin Röösli and Nicole Probst-Hensch
Additional contact information
Ikenna C. Eze: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Medea Imboden: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Maria Foraster: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Emmanuel Schaffner: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Ashish Kumar: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Danielle Vienneau: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Harris Héritier: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Franziska Rudzik: Center for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4056 Basel, Switzerland
Laurie Thiesse: Center for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4056 Basel, Switzerland
Reto Pieren: Empa, Laboratory for Acoustics/Noise Control, Swiss Federal Laboratories for Material Science and Technology, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland
Arnold Von Eckardstein: Institute of Clinical Chemistry, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland
Christian Schindler: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Mark Brink: Federal Office for the Environment, 3003 Bern, Switzerland
Jean-Marc Wunderli: Empa, Laboratory for Acoustics/Noise Control, Swiss Federal Laboratories for Material Science and Technology, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland
Christian Cajochen: Center for Chronobiology, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4056 Basel, Switzerland
Martin Röösli: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland
Nicole Probst-Hensch: Swiss Tropical and Public Health Institute, Socinstrasse 57, P.O. Box, CH-4002 Basel, Switzerland

IJERPH, 2017, vol. 14, issue 12, 1-18

Abstract: Traffic noise has been linked to diabetes, with limited understanding of its mechanisms. We hypothesize that night-time road traffic noise (RTN) may impair glucose homeostasis through circadian rhythm disturbances. We prospectively investigated the relationship between residential night-time RTN and subsequent eight-year change in glycosylated hemoglobin (?HbA1c) in 3350 participants of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), adjusting for diabetes risk factors and air pollution levels. Annual average RTN (Lnight) was assigned to participants in 2001 using validated Swiss noise models. HbA1c was measured in 2002 and 2011 using liquid chromatography. We applied mixed linear models to explore RTN–?HbA1c association and its modification by a genetic risk score of six common circadian-related MTNR1B variants (MGRS). A 10 dB difference in RTN was associated with a 0.02% (0.003–0.04%) increase in mean ?HbA 1c in 2142 non-movers. RTN–?HbA1c association was modified by MGRS among diabetic participants ( P interaction = 0.001). A similar trend in non-diabetic participants was non-significant. Among the single variants, we observed strongest interactions with rs10830963, an acknowledged diabetes risk variant also implicated in melatonin profile dysregulation. Night-time RTN may impair glycemic control, especially in diabetic individuals, through circadian rhythm disturbances. Experimental sleep studies are needed to test whether noise control may help individuals to attain optimal glycemic levels.

Keywords: transportation noise; MTNR1B gene; rs10830963; diabetes; glycosylated hemoglobin; circadian sleep-wake cycle; gene-environment interactions; adults; cohort study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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