Maternal Exposure to Pyrethroid Insecticides during Pregnancy and Infant Development at 18 Months of Age

Aya Hisada, Jun Yoshinaga, Jie Zhang, Takahiko Katoh, Hiroaki Shiraishi, Kazuhisa Shimodaira, Takashi Okai, Nagako Ariki, Yoko Komine, Miyako Shirakawa, Yumiko Noda and Nobumasa Kato
Additional contact information
Aya Hisada: Department of Public Health, Faculty of Life Sciences, Kumamoto University, Honjyo 1-1-1, Chuo-ku, Kumamoto 860-8556, Japan
Jun Yoshinaga: Department of Environmental Systems, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8563, Japan
Jie Zhang: Department of Environmental Systems, University of Tokyo, Kashiwanoha 5-1-5, Kashiwa, Chiba 277-8563, Japan
Takahiko Katoh: Department of Public Health, Faculty of Life Sciences, Kumamoto University, Honjyo 1-1-1, Chuo-ku, Kumamoto 860-8556, Japan
Hiroaki Shiraishi: National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, Ibaraki 305-8056, Japan
Kazuhisa Shimodaira: Department of Obstetrics and Gynecology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
Takashi Okai: Department of Obstetrics and Gynecology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
Nagako Ariki: Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
Yoko Komine: Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
Miyako Shirakawa: Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
Yumiko Noda: Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan
Nobumasa Kato: Department of Psychiatry and Neurology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa, Tokyo 142-8555, Japan

IJERPH, 2017, vol. 14, issue 1, 1-9

Abstract: The possible association between maternal exposure to pyrethroid insecticides (PYRs) during pregnancy and infant development was explored. Levels of exposure to PYRs was assessed by metabolite (3-phenoybenzoic acid, 3-PBA) concentration in maternal spot urine sampled in the first trimester of index pregnancy, and infant development was assessed at 18 months of age using the Kinder Infants Development Scale (KIDS), which is based on a questionnaire to the caretaker. The relationship between KIDS score and maternal urinary 3-PBA levels was examined by a stepwise multiple regression analysis using biological attributes of the mother and infant, breast feeding, and nursing environment as covariates. The analysis extracted 3-PBA and the nursing environment as significant to explain the KIDS score at 18 months of age with positive partial regression coefficients. Inclusion of fish consumption frequency of the mother during pregnancy as an independent variable resulted in the selection of fish consumption as significant, while the two variables were marginally insignificant but still with a positive coefficient with the KIDS score. The result suggested a positive effect of maternal PYR exposure on infant development, the reason for which is not clear, but an unknown confounding factor is suspected.

Keywords: pyrethroid insecticide; urinary 3-phenoxybenzoic acid; in utero exposure; child development; KIDS (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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