Meta-Prediction of the Effect of Methylenetetrahydrofolate Reductase Polymorphisms and Air Pollution on Alzheimer’s Disease Risk

Suh-Mian Wu, Zhao-Feng Chen, Lufei Young and S. Pamela K. Shiao
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Suh-Mian Wu: Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan
Zhao-Feng Chen: Department of Nursing, Yuanpei University of Medical Technology, No.306, Yuanpei Street, Hsinchu 30015, Taiwan
Lufei Young: College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA
S. Pamela K. Shiao: College of Nursing, Augusta University (Previously Georgia Regents University), 987 St. Sebastian Way, EC 4505, Augusta, GA 30912, USA

IJERPH, 2017, vol. 14, issue 1, 1-14

Abstract: Background : Alzheimer’s disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase ( MTHFR ) C677T polymorphism, but the findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations between MTHFR polymorphisms and epigenetic factors, including air pollution, with AD risk using big data analytics approaches. Methods and Results : Forty-three studies (44 groups) were identified by searching various databases. MTHFR C677T TT and CT genotypes had significant associations with AD risk in all racial populations (RR = 1.13, p = 0.0047; and RR = 1.12, p < 0.0001 respectively). Meta-predictive analysis showed significant increases of percentages of MTHFR C677T polymorphism with increased air pollution levels in both AD case group and control group ( p = 0.0021–0.0457); with higher percentages of TT and CT genotypes in the AD case group than that in the control group with increased air pollution levels. Conclusions : The impact of MTHFR C677T polymorphism on susceptibility to AD was modified by level of air pollution. Future studies are needed to further examine the effects of gene-environment interactions including air pollution on AD risk for world populations.

Keywords: meta-analysis; methylenetetrahydrofolate reductase gene; Alzheimer’s disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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