Toxicity Research of PM 2.5 Compositions In Vitro

Yi-Yang Jia, Qi Wang and Te Liu
Additional contact information
Yi-Yang Jia: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Qi Wang: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Te Liu: Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China

IJERPH, 2017, vol. 14, issue 3, 1-17

Abstract: According to the published literature, we surmise that particulate matter (PM) concentration, individually, may be less important than components in explaining health effects. PM 2.5 (aerodynamic diameter <2.5 ?m) had similar cytotoxicity (e.g., cell viability reduction, oxidative damage, inflammatory effects and genetic toxicity) on different types of cells. The studies of cells are readily available for detailed mechanistic investigations, which is more appropriate for learning and comparing the mechanism caused by single or mixed ingredients coating a carbon core. No review exists that holistically examines the evidence from all components-based in vitro studies. We reviewed published studies that focus on the cytotoxicity of normal PM 2.5 . Those studies suggested that the toxicity of mixed compositions differs greatly from the single ingredients in mixed components and the target cells. The cytotoxic responses caused by PM 2.5 components have not shown a consistent association with clear, specific health effects. The results may be beneficial for providing new targets for drugs for the treatment of PM 2.5 -related diseases.

Keywords: cell; particular matter; components; toxicology; health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/14/3/232/pdf (application/pdf)
https://www.mdpi.com/1660-4601/14/3/232/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:14:y:2017:i:3:p:232-:d:91550

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().