Long Non-Coding RNA as Potential Biomarker for Prostate Cancer: Is It Making a Difference?

Junli Deng, Jie Tang, Guo Wang and Yuan-Shan Zhu
Additional contact information
Junli Deng: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Jie Tang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Guo Wang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Yuan-Shan Zhu: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China

IJERPH, 2017, vol. 14, issue 3, 1-16

Abstract: Whole genome transcriptomic analyses have identified numerous long non-coding RNA (lncRNA) transcripts that are increasingly implicated in cancer biology. LncRNAs are found to promote essential cancer cell functions such as proliferation, invasion, and metastasis, with the potential to serve as novel biomarkers of various cancers and to further reveal uncharacterized aspects of tumor biology. However, the biological and molecular mechanisms as well as the clinical applications of lncRNAs in diverse diseases are not completely understood, and remain to be fully explored. LncRNAs may be critical players and regulators in prostate cancer carcinogenesis and progression, and could serve as potential biomarkers for prostate cancer. This review focuses on lncRNA biomarkers that are already available for clinical use and provides an overview of lncRNA biomarkers that are under investigation for clinical development in prostate cancer.

Keywords: prostate cancer; lncRNAs; PCA3; biomarkers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/14/3/270/pdf (application/pdf)
https://www.mdpi.com/1660-4601/14/3/270/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:14:y:2017:i:3:p:270-:d:92415

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().