Enterovirus 71 Neutralizing Antibodies Seroepidemiological Research among Children in Guangzhou, China between 2014 and 2015: A Cross-Sectional Study

Dingmei Zhang, Yan Chen, Xiashi Chen, Zhenjian He, Xun Zhu and Yuantao Hao
Additional contact information
Dingmei Zhang: School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
Yan Chen: Medical College of Shaoguan University, No.1 Xinhuanan Road, Shaoguan 512000, China
Xiashi Chen: School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
Zhenjian He: School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
Xun Zhu: Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China
Yuantao Hao: School of Public Health, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou 510080, China

IJERPH, 2017, vol. 14, issue 3, 1-9

Abstract: A hand-foot-mouth disease outbreak occurred in 2014 around Guangdong. The purpose of this study was investigating the status and susceptibility of infectious neutralizing antibodies to enterovirus 71 among children so as to provide scientific evidence for the population immunity level of hand-foot-mouth disease and prepare for enterovirus 71 vaccination implementation. Serum specimens were collected from children in communities from January 2014 to March 2015 in Guangzhou. A total of 197 serum samples from children 1–5 years old were collected for this cross-sectional study via non-probabilistic sampling from the database of Chinese National Science and Technique Major Project. Neutralization activity was measured via micro neutralization test in vitro. The positive rate of enterovirus 71 neutralizing antibodies was 59.4%, whereas the geometric mean titre was 1:12.7. A statistically significant difference in true positive rates was found between different age groups but not between different genders. Being the most susceptible population of hand–foot–mouth disease, children under 3 years of age are more likely to be infected with enterovirus 71, and the immunity of children increases with increasing age. Further cohort studies should be conducted, and measures for prevention and vaccination should be taken.

Keywords: hand-foot-mouth disease; enterovirus 71; neutralizing antibodies; seroepidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/14/3/319/pdf (application/pdf)
https://www.mdpi.com/1660-4601/14/3/319/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:14:y:2017:i:3:p:319-:d:93583

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().