Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a Cadmium-Polluted Area in Thailand

Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn and Yoshikazu Nishino
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Muneko Nishijo: Department of Public Health, Kanazawa Medical University Hospital, Uchinada 920-0293, Japan
Kowit Nambunmee: School of Health Science, Mae Fah Luang University, Chiang Rai 57100, Thailand
Dhitiwass Suvagandha: Environmental Science Program, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Witaya Swaddiwudhipong: Mae Sot General Hospital, Mae Sot District, Tak Province 63110, Thailand
Werawan Ruangyuttikarn: Department of Forensic Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Yoshikazu Nishino: Department of Public Health, Kanazawa Medical University Hospital, Uchinada 920-0293, Japan

IJERPH, 2017, vol. 14, issue 4, 1-11

Abstract: To elucidate the influence of cadmium exposure on bone metabolism, associations between urinary/blood cadmium and bone resorption/formation markers were investigated in older cadmium exposed men and women. Increased urinary cross-linked N-telopeptide of type I collagen (NTx), a bone resorption marker, was found to be associated with increased levels of parathyroid hormone, fractional excretion of calcium, and urinary/blood cadmium after adjusting for confounding factors in men. In women, urinary NTx was significantly associated with only urinary cadmium and a strong relationship with increased fractional excretion of calcium. Risk for bone metabolic disorders, indicated by high urinary NTx, significantly increased in men with blood cadmium ? 10 ?g/L or urinary cadmium ? 10 ?g/g creatinine. Increased osteocalcin level was significantly associated with increased blood cadmium in men. In conclusion, cadmium exposure appeared to have an influence on bone remodeling both bone resorption and formation in this population of older Thai men, and blood cadmium was more closely associated with bone metabolism than urinary cadmium.

Keywords: blood cadmium; urinary cadmium; bone resorption marker; bone formation marker; whole parathyroid hormone; vitamin D binding protein; Thailand (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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