Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines—Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Andrzej Prystupa, Paweł Kiciński, Dorota Luchowska-Kocot, Anna Błażewicz, Jarosław Niedziałek, Grzegorz Mizerski, Mariusz Jojczuk, Andrzej Ochal, Jarosław J. Sak and Wojciech Załuska
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Andrzej Prystupa: Department of Internal Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
Paweł Kiciński: Department of Family Medicine, Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland
Dorota Luchowska-Kocot: Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a (Collegium Pharmaceuticum), 20-093 Lublin, Poland
Anna Błażewicz: Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a (Collegium Pharmaceuticum), 20-093 Lublin, Poland
Jarosław Niedziałek: Individual Medical Practice, Lublin, Ludwika Hirszfelda 5/11, 20-092 Lublin, Poland
Grzegorz Mizerski: Department of Family Medicine, Medical University of Lublin, Staszica 11, 20-081 Lublin, Poland
Mariusz Jojczuk: Department of Trauma Surgery and Emergency Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
Andrzej Ochal: Department of Trauma Surgery and Emergency Medicine, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
Jarosław J. Sak: Department of Ethics and Human Philosophy, Medical University of Lublin, Staszica 4/6 (Collegium Maximum), 20-059 Lublin, Poland
Wojciech Załuska: Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland

IJERPH, 2017, vol. 14, issue 4, 1-9

Abstract: According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines—interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.

Keywords: alcohol; liver cirrhosis; selenium; interleukin-6; growth differentiation factor-15 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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