Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease

Yaqin Wang, Xintong Wang, Zhenyu Li, Lulu Chen, Luping Zhou, Chaopeng Li and Dong-sheng Ouyang
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Yaqin Wang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Xintong Wang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Zhenyu Li: Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China
Lulu Chen: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Luping Zhou: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Chaopeng Li: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Dong-sheng Ouyang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China

IJERPH, 2017, vol. 14, issue 5, 1-7

Abstract: The coronary artery disease (CAD) is one of the most severe cardiovascular diseases. MicroRNA-146a (miR-146a) influences the pathology of cardiovascular diseases. Two single nucleotide polymorphisms (SNPs) of miR-146a (rs2431697 and rs2910164) have been reported to alter the function or expression of microRNA. The purpose of this study is to evaluate the association between miR-146a gene polymorphism and the risk of CAD in the Chinese population. A total of 353 CAD patients and 368 controls were recruited, and SNPs were analyzed by the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and Sequenom MassARRAY system. The gene frequencies of rs2431697 and rs2910164 were significantly different between the two groups. The mutant type (T allele) of rs2431697 and wild type (C allele) of rs2910164 were more frequent in CAD patients. T allele carriers in rs2431697 had an increased CAD risk, while G allele of rs2910164 decreased the risk of CAD significantly. In conclusion, we found that the T allele of rs2431697 was a risk factor of CAD in the Chinese population. Meanwhile, we demonstrated that the G allele of rs2910164 decreased the susceptibility of CAD.

Keywords: microRNA-146a; coronary artery disease; gene polymorphism (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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