Systematic Review and Meta-Analysis of the Association between Ambient Nitrogen Dioxide and Respiratory Disease in China

Jiyao Sun, Andrew J. Barnes, Dongyang He, Meng Wang and Jian Wang
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Jiyao Sun: School of Health Care Management, Shandong University, Key Laboratory of Health Economics and Policy Research, National Health and Family Planning Commission of People’s Republic of China (NHFPC), Shandong University, 44 West Wenhua Road, Jinan 250012, China
Andrew J. Barnes: Department of Health Behavior and Policy, School of Medicine, Virginia Commonwealth University, 830 E Main St., Richmond, VA 23219, USA
Dongyang He: School of Health Care Management, Shandong University, Key Laboratory of Health Economics and Policy Research, National Health and Family Planning Commission of People’s Republic of China (NHFPC), Shandong University, 44 West Wenhua Road, Jinan 250012, China
Meng Wang: School of Health Care Management, Shandong University, Key Laboratory of Health Economics and Policy Research, National Health and Family Planning Commission of People’s Republic of China (NHFPC), Shandong University, 44 West Wenhua Road, Jinan 250012, China
Jian Wang: School of Health Care Management, Shandong University, Key Laboratory of Health Economics and Policy Research, National Health and Family Planning Commission of People’s Republic of China (NHFPC), Shandong University, 44 West Wenhua Road, Jinan 250012, China

IJERPH, 2017, vol. 14, issue 6, 1-16

Abstract: Objective: This study aimed to assess the quantitative effects of short-term exposure of ambient nitrogen dioxide (NO 2 ) on respiratory disease (RD) mortality and RD hospital admission in China through systematic review and meta-analysis. Methods: A total of 29 publications were finally selected from searches in PubMed, Web of Science, CNKI and Wanfang databases. Generic inverse variance method was used to pool effect estimates. Pooled estimates were used to represent the increased risk of RD mortality and RD hospital admission per 10 ?g/m 3 increase in NO 2 concentration. Results: Positive correlations were found between short-term NO 2 exposure and RD in China. RD mortality and RD hospital admission respectively increased by 1.4% (95% CI: 1.1%, 1.7%) and 1.0% (95% CI: 0.5%, 1.5%) per 10 ?g/m 3 increase in NO 2 concentration. Differences were observed across geographic regions of China. The risk of RD mortality due to NO 2 was higher in the southern region (1.7%) than in the north (0.7%). Conclusions : Evidence was found that short-term exposure to NO 2 was associated with an increased risk of RD mortality and RD hospital admission in China and these risks were more pronounced in the southern regions of the country, due in part to a larger proportion of elderly persons with increased susceptibility to NO 2 in the population compared with the north.

Keywords: nitrogen dioxide; respiratory disease; hospital admission; China (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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