The Cell Surface Markers Expression in Postmenopausal Women and Relation to Obesity and Bone Status

Mira Horváthová, Silvia Ilavská, Kornélia Štefíková, Michaela Szabová, Zora Krivošíková, Eva Jahnová, Jana Tulinská, Viera Spustová and Martin Gajdoš
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Mira Horváthová: Department of Immunology and Immunotoxicology, Faculty of Medicine, Slovak Medical University, 833 03 Bratislava, Slovakia
Silvia Ilavská: Department of Immunology and Immunotoxicology, Faculty of Medicine, Slovak Medical University, 833 03 Bratislava, Slovakia
Kornélia Štefíková: Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Slovak Medical University, 83303 Bratislava, Slovakia
Michaela Szabová: Department of Immunology and Immunotoxicology, Faculty of Medicine, Slovak Medical University, 833 03 Bratislava, Slovakia
Zora Krivošíková: Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Slovak Medical University, 83303 Bratislava, Slovakia
Eva Jahnová: Department of Immunology and Immunotoxicology, Faculty of Medicine, Slovak Medical University, 833 03 Bratislava, Slovakia
Jana Tulinská: Department of Immunology and Immunotoxicology, Faculty of Medicine, Slovak Medical University, 833 03 Bratislava, Slovakia
Viera Spustová: Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Slovak Medical University, 83303 Bratislava, Slovakia
Martin Gajdoš: Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Slovak Medical University, 83303 Bratislava, Slovakia

IJERPH, 2017, vol. 14, issue 7, 1-14

Abstract: The age-related changes and hormonal deprivation in postmenopausal women are associated with the immune response alteration. The excessive fat accumulation, local and systemic inflammation may lead to dysregulation in immune function and relevant health problems, including obesity and osteoporosis. We analyzed the expression of cell surface markers in the venous blood specimens, stained with fluorophores-conjugated monoclonal antibodies and analysed by multicolour flow cytometry. The significant changes of cytotoxic, naive, and memory T-lymphocytes, plasmacytoid dendritic cells (DCs) were in postmenopausal women versus fertile women. Body mass index (BMI) affected markedly the cell surface expression of CD265/RANK. Osteoporosis is linked to reduced percentage of plasmacytoid DCs, and elevated natural Treg cells ( p < 0.05). The confounding factors such as women age, BMI, bone mineral density (BMD), waist size and tissue fat affect the expression of RANK on myeloid DCs and CD40L on T-lymphocytes that might be the immunophenotypic modulators after menopause.

Keywords: cell surface molecules; postmenopausal women; obesity; bone status; inflammation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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