Unusual Onset of Celiac Disease and Addison’s Disease in a 12-Year-Old Boy

Francesco Miconi, Emanuela Savarese, Giovanni Miconi, Gabriele Cabiati, Valentina Rapaccini, Nicola Principi and Susanna Esposito
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Francesco Miconi: Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
Emanuela Savarese: Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
Giovanni Miconi: Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
Gabriele Cabiati: Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
Valentina Rapaccini: Paediatric Clinic, Azienda Ospedaliera di Terni, 05100 Terni, Italy
Nicola Principi: Pediatric Highly Intensive Care Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, 20122 Milan, Italy
Susanna Esposito: Paediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy

IJERPH, 2017, vol. 14, issue 8, 1-6

Abstract: Background: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison’s disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD. Case presentation: A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here. A gluten-free diet had a significant therapeutic role in this case, wherein most of the clinical signs and symptoms of AD disappeared in a few days. In addition, the dosage of cortisol acetate, initially administered to treat the AD, was able to be rapidly reduced. Conclusion: This case highlights that CD can be associated with AD in children, and a gluten-free diet seems to positively influence the course of AD.

Keywords: Addison’s disease; autoimmune diseases; celiac disease; gluten-free diet (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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