The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies

Xinge Zhang, Rui Zhang, Justin B. Moore, Yueqiao Wang, Hanyi Yan, Yingru Wu, Anran Tan, Jialin Fu, Ziqiong Shen, Guiyu Qin, Rui Li and Guoxun Chen
Additional contact information
Xinge Zhang: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Rui Zhang: College of Life Sciences, South-Central University for Nationalities, Wuhan 430074, China
Justin B. Moore: Department of Family and Community Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Yueqiao Wang: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Hanyi Yan: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Yingru Wu: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Anran Tan: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Jialin Fu: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Ziqiong Shen: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Guiyu Qin: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Rui Li: School of Health Sciences, Wuhan University, 115 Donghu Road, Wuhan 430071, China
Guoxun Chen: Department of Nutrition, The University of Tennessee, Knoxville, TN 37996, USA

IJERPH, 2017, vol. 14, issue 9, 1-15

Abstract: This meta-analysis evaluated the influence of dietary intake and blood level of vitamin A (total vitamin A, retinol or ?-carotene) on total and hip fracture risk. Cohort studies published before July 2017 were selected through English-language literature searches in several databases. Relative risk (RR) with corresponding 95% confidence interval (CI) was used to evaluate the risk. Heterogeneity was checked by Chi-square and I 2 test. Sensitivity analysis and publication bias were also performed. For the association between retinol intake and total fracture risk, we performed subgroup analysis by sex, region, case ascertainment, education level, age at menopause and vitamin D intake. R software was used to complete all statistical analyses. A total of 319,077 participants over the age of 20 years were included. Higher dietary intake of retinol and total vitamin A may slightly decrease total fracture risk (RR with 95% CI: 0.95 (0.91, 1.00) and 0.94 (0.88, 0.99), respectively), and increase hip fracture risk (RR with 95% CI: 1.40 (1.02, 1.91) and 1.29 (1.06, 1.57), respectively). Lower blood level of retinol may slightly increase total fracture risk (RR with 95% CI: 1.11 (0.94, 1.30)) and hip fracture risk (RR with 95% CI: 1.27 (1.05, 1.53)). In addition, higher ?-carotene intake was weakly associated with the increased risk of total fracture (RR with 95% CI: 1.07 (0.97, 1.17)). Our data suggest that vitamin A intake and level may differentially influence the risks of total and hip fractures. Clinical trials are warranted to confirm these results and assess the clinical applicability.

Keywords: vitamin A; retinol; ?-carotene; hip fracture; total fracture (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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