Is There Any Relationship between Plasma 25-Hydroxyvitamin D 3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?

Joanna Kocot, Piotr Dziemidok, Małgorzata Kiełczykowska, Jacek Kurzepa, Grzegorz Szcześniak and Irena Musik
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Joanna Kocot: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland
Piotr Dziemidok: Diabetology Ward, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
Małgorzata Kiełczykowska: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland
Jacek Kurzepa: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland
Grzegorz Szcześniak: Diabetology Ward, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland
Irena Musik: Chair and Department of Medical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland

IJERPH, 2017, vol. 15, issue 1, 1-13

Abstract: A growing interest in the role of vitamin D in metabolic diseases led us to study the relationships between 25-hydroxyvitamin D 3 (25(OH)D 3 ) and the profiles of selected adipokines in type 2 diabetic (T2DM) patients. The study comprised 92 type 2 diabetics divided into quartiles regarding 25(OH)D 3 concentration. Each group was divided into male and female subgroups. All the studied patients had their anthropometric and biochemical parameters determined. Plasma 25-hydroxyvitamin D 3 concentration was determined by HPLC, while the selected adipokines (leptin, adiponectin, resistin and visfatin) by ELISA methods. The ratio of leptin to adiponectin (L/A) was calculated for all the patients. In 85.3% of diabetics a full (<20 ng/mL) or moderate (20–30 ng/mL) vitamin D deficit was found. Irrespective of sex, plasma leptin concentration decreased across increasing quartiles of 25(OH)D 3 level. In women, 25(OH)D 3 was negatively correlated with BMI, leptin level as well as L/A ratio, and positively with adiponectin concentration. In men, 25(OH)D 3 was positively correlated with HDL and negatively with systolic blood pressure (SBP), leptin level and L/A ratio. Considering all the patients, there ocurred a significant negative correlation between 25(OH)D 3 and SBP, BMI, WHR, TG, leptin and L/A ratio and positive ones between 25(OH)D 3 and both adiponectin and HDL. The results of the study support the existence of the relationship among vitamin D, obesity and leptin in type 2 diabetic patients.

Keywords: vitamin D; adipokines; type 2 diabetes; obesity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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