Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus

Sugunadevi Sakkiah, Tony Wang, Wen Zou, Yuping Wang, Bohu Pan, Weida Tong and Huixiao Hong
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Sugunadevi Sakkiah: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Tony Wang: Department of Biology, Arkansas University, Fayetteville, AR 72701, USA
Wen Zou: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Yuping Wang: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Bohu Pan: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Weida Tong: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA
Huixiao Hong: National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA

IJERPH, 2017, vol. 15, issue 1, 1-17

Abstract: Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer’s disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the structural basis and interactions between androgen receptor and EDCs as well as the associations of various types of diabetes mellitus with the EDCs mediated through androgen receptor binding. We also discuss the perspective research for further understanding the impact and mechanisms of EDCs on the risk of diabetes mellitus.

Keywords: androgen receptor; diabetes mellitus; metabolic syndrome; cancer; androgenic activity compounds (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2017
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