Factors Associated with the Risk of Developing Coronary Artery Disease in Medicated Patients with Major Depressive Disorder

Roger C. M. Ho, Anna C. Chua, Bach X. Tran, Carol C. Choo, Syeda Fabeha Husain, Giang T. Vu, Roger S. McIntyre and Cyrus S. H. Ho
Additional contact information
Roger C. M. Ho: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
Anna C. Chua: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
Bach X. Tran: Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam
Carol C. Choo: College of Healthcare Sciences, James Cook University, Singapore 387380, Singapore
Syeda Fabeha Husain: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore
Giang T. Vu: Institute for Global Health Innovations, Duy Tan University, Hanoi 73000, Vietnam
Roger S. McIntyre: Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada
Cyrus S. H. Ho: Department of Psychological Medicine, National University Health System, Singapore 119228, Singapore

IJERPH, 2018, vol. 15, issue 10, 1-13

Abstract: Background: The aim of this study was to identify factors associated with high Framingham Risk Score (FRS) in medicated patients with major depressive disorder (MDD). Methods: We examined 61 medicated patients with MDD (mean age 37.77 ± 7.67, 90.2% women) and 43 non-depressed controls (mean age 38.26 ± 9.20, 90.7% women). We administered the Hamilton Depression Rating Scale (HAM-D) and measured systolic blood pressure (SBP), diastolic BP (DBP), mean arterial BP (MAP), pulse wave velocity (PWV), intima-media thickness (IMT), interleukin-6 (IL-6) and triglycerides. Results: We found that medicated patients with MDD had significantly higher levels of HAM-D score ( p < 0.01), SBP ( p = 0.015), MAP ( p = 0.037), IL−6 level ( p = 0.007), as compared with controls. Medicated patients who remained moderately to severely depressed showed significantly higher SBP ( p = 0.049), DBP ( p = 0.009), MAP ( p = 0.024), IL−6 level ( p = 0.019), left PWV ( p = 0.004) and average PWV ( p = 0.026) than those with mild depression. Multivariate regression showed that the interaction effect between HAM-D score and triglyceride level ( p = 0.018) was significantly associated with FRS in medicated patients with MDD. Conclusions: This study highlights that the interaction effect of the severity of depression and the triglyceride level, was a modifiable factor positively associated with high FRS.

Keywords: antidepressants; cytokines; depression; Framingham risk score; Hamilton depression rating scale; pulse wave velocity; triglycerides (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.mdpi.com/1660-4601/15/10/2073/pdf (application/pdf)
https://www.mdpi.com/1660-4601/15/10/2073/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:15:y:2018:i:10:p:2073-:d:171300

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().