Seroprevalence and Determinants Associated with Mumps Antibodies after 20 Years of MMR Vaccination in Urban Area of Shanghai, China

Hong Pang, Yibiao Zhou, Wensui Zhao and Qingwu Jiang
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Hong Pang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
Yibiao Zhou: Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
Wensui Zhao: Changning Center for Disease Control and Prevention, Shanghai 200051, China
Qingwu Jiang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China

IJERPH, 2018, vol. 15, issue 10, 1-11

Abstract: A resurgence of the mumps epidemic in highly vaccinated populations has occurred in recent years in many countries. This study aimed to evaluate the seroprevalence to mumps in urban areas of Shanghai, where a measles-mumps-rubella (MMR) vaccination had been implemented for 20 years. Mumps IgG antibodies were tested in 2662 residual sera from all ages in an urban area of Shanghai. A linear regression method was performed to assess the persistence of mumps antibodies after MMR vaccination. A logistic regression method was used to analyze the variables associated with seronegative sera. The overall age- and gender-adjusted seroprevalence of mumps antibodies reached 90% (95% CI: 90.0–90.2). The antibody concentration declined significantly in the first eight years after the second dose of MMR. The multivariate analysis identified that males, age groups, especially 17–19 years and no dose of vaccination, as well as one dose of vaccination, as factors associated with an increased risk of seronegative sera. A high seroprevalence to mumps has been achieved in the urban areas of Shanghai. A declining antibody level of mumps after the second dose of MMR may put a potential risk of recurrence of mumps. The two-dose MMR vaccine schedule is superior to one-dose schedule for mumps control.

Keywords: mumps; seroprevalence; vaccination; humoral immunity; MMR vaccine (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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