Associations of Physical Behaviours and Behavioural Reallocations with Markers of Metabolic Health: A Compositional Data Analysis

Gregory J. H. Biddle, Charlotte L. Edwardson, Joseph Henson, Melanie J. Davies, Kamlesh Khunti, Alex V. Rowlands and Thomas Yates
Additional contact information
Gregory J. H. Biddle: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK
Charlotte L. Edwardson: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK
Joseph Henson: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK
Melanie J. Davies: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK
Kamlesh Khunti: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK
Alex V. Rowlands: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK
Thomas Yates: Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK

IJERPH, 2018, vol. 15, issue 10, 1-14

Abstract: Standard statistical modelling has shown that the reallocation of sitting time to either standing or stepping may be beneficial for metabolic health. However, this overlooks the inherent dependency of time spent in all behaviours. The aim is to examine the associations between physical behaviours and markers of metabolic health (fasting glucose, fasting insulin, 2-h glucose, 2-h insulin, Homeostasis Model Assessment of Insulin Sensitivity (HOMA-IS), Matsuda Insulin Sensitivity Index (Matsuda-ISI) while quantifying the associations of reallocating time from one physical behaviour to another using compositional analysis. Objectively measured physical behaviour data were analysed ( n = 435) using compositional analysis and compositional isotemporal substitutions to estimate the association of reallocating time from one behaviour to another in a population at high risk of type 2 diabetes mellitus (T2DM). Stepping time was associated with all markers of metabolic health relative to all other behaviours. Reallocating 30 min from sleep, sitting, or standing to stepping was associated with 5–6 fold lower 2-h glucose, 15–17 fold lower 2-h insulin, and higher insulin sensitivity (10–11 fold via HOMA-IS, 12–15 fold via Matsuda-ISI). Associations of reallocating time from any behaviour to stepping were maintained for 2-h glucose, 2-h insulin, and Matsuda-ISI after further adjusting for body mass index (BMI). Relocating time from stepping into sleep, sitting, or standing was associated with lower insulin sensitivity. Stepping time may be the most important behavioural composition when promoting improved metabolic health in adults at risk of T2DM.

Keywords: sleep; sedentary behaviour; physical activity; time use; metabolic health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations: View citations in EconPapers (7)

Downloads: (external link)
https://www.mdpi.com/1660-4601/15/10/2280/pdf (application/pdf)
https://www.mdpi.com/1660-4601/15/10/2280/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:15:y:2018:i:10:p:2280-:d:176319

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().