Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle

Jun-Won Heo, Su-Zi Yoo, Mi-Hyun No, Dong-Ho Park, Ju-Hee Kang, Tae-Woon Kim, Chang-Ju Kim, Dae-Yun Seo, Jin Han, Jin-Hwan Yoon, Su-Jeen Jung and Hyo-Bum Kwak
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Jun-Won Heo: Department of Kinesiology, Inha University, Incheon 22212, Korea
Su-Zi Yoo: Department of Kinesiology, Inha University, Incheon 22212, Korea
Mi-Hyun No: Department of Kinesiology, Inha University, Incheon 22212, Korea
Dong-Ho Park: Department of Kinesiology, Inha University, Incheon 22212, Korea
Ju-Hee Kang: Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon 22212, Korea
Tae-Woon Kim: Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea
Chang-Ju Kim: Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea
Dae-Yun Seo: National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
Jin Han: National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
Jin-Hwan Yoon: Department of Kinesiology, Hannam University, Daejeon 34430, Korea
Su-Jeen Jung: Department of Leisure Sports, Seoil University, Seoul 02192, Korea
Hyo-Bum Kwak: Department of Kinesiology, Inha University, Incheon 22212, Korea

IJERPH, 2018, vol. 15, issue 10, 1-12

Abstract: Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle remodeling and mitochondria-mediated apoptosis in obese skeletal muscles have not been clearly elucidated. Four-week-old C57BL/6 mice were randomly assigned into four groups: control (CON), control plus exercise (CON + EX), high-fat diet (HFD), and HFD plus exercise groups (HFD + EX). After obesity was induced by 20 weeks of 60% HFD feeding, treadmill exercise was performed for 12 weeks. Exercise ameliorated the obesity-induced increase in extramyocyte space and a decrease in the cross-sectional area of the skeletal muscle. In addition, it protected against increases in mitochondria-mediated apoptosis in obese skeletal muscles. These results suggest that exercise as a protective intervention plays an important role in regulating skeletal muscle structure and apoptosis in obese skeletal muscles.

Keywords: obesity; exercise; skeletal muscle; mitochondria; apoptosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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