Dialysis Membranes Influence Perfluorochemical Concentrations and Liver Function in Patients on Hemodialysis

Wen-Sheng Liu, Hsiang Lin Chan, Yen-Ting Lai, Chih-Ching Lin, Szu-Yuan Li, Chih-Kuang Liu, Han-Hsing Tsou and Tsung-Yun Liu
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Wen-Sheng Liu: Division of Nephrology, Department of Medicine, Taipei City Hospital, Zhongxing Branch, Taipei 10466, Taiwan
Hsiang Lin Chan: Department of Child Psychiatry, Chang Gung Memorial Hospital and University, Taoyuan 33043, Taiwan
Yen-Ting Lai: Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu 30041, Taiwan
Chih-Ching Lin: School of Medicine, National Yang-Ming University, Taipei 10466, Taiwan
Szu-Yuan Li: School of Medicine, National Yang-Ming University, Taipei 10466, Taiwan
Chih-Kuang Liu: College of Medicine and Graduate Institute of Business Administration, Fu Jen Catholic University, New Taipei City 24451, Taiwan
Han-Hsing Tsou: Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 10466, Taiwan
Tsung-Yun Liu: Institute of Environmental and Occupational Health Sciences, School of Medicine, National Yang-Ming University, Taipei 10466, Taiwan

IJERPH, 2018, vol. 15, issue 11, 1-12

Abstract: Introduction : Perfluoro-octanesulfonate (PFOS) and perfluoro-octanoic acid (PFOA) are two toxic perfluorochemicals (PFCs) commonly used as surfactants. PFCs are difficult to be eliminated from the body. We investigated the influence of different dialysis membranes on the concentrations of PFCs in patients under hemodialysis. Method : We enrolled 98 patients. Of these, 58 patients used hydrophobic polysulfone (PS) dialysis membranes, and the other 40 had hydrophilic membranes made by poly-methyl methacrylate (PMMA) or cellulose triacetate (CTA). Liquid chromatography tandem mass spectrometry coupled was used with isotope dilution to quantify PFOA and PFOS. Results : The predialysis concentrations of PFOA and PFOS in patients with hydrophobic PS dialysis membranes were 0.50 and 15.77 ng/mL, respectively, lower than the concentrations of 0.81 and 22.70 ng/mL, respectively, in those who used hydrophilic membranes (such as CTA or PMMA). Older patients have higher PFOS and poorer body function, with lower Karnofsky Performance Status Scale (KPSS) scores. The demographic data of the two groups were similar. However, patients with hydrophobic PS dialysis membranes had lower predialysis aspartate transaminase (AST) ( p = 0.036), lower glucose levels ( p = 0.017), and better body function (nonsignificantly higher KPSS scores, p = 0.091) compared with patients who used other membranes. These differences may be associated with the effects of different membranes, because PFOA positively correlated with AST, while PFOS negatively correlated with body function. Conclusions : This is the first study comparing PFC levels in uremic patients with different dialysis membrane. PS membrane may provide better clearance of PFCs and may, therefore, be beneficial for patients.

Keywords: perfluorochemicals; hemodialysis; dialysis membrane; polysulfone; LC-MS/MS (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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