Increased Risk of Ulcerative Colitis in Patients with Periodontal Disease: A Nationwide Population-Based Cohort Study

Chien-Yu Lin, Kuo-Sen Tseng, Jui-Ming Liu, Heng-Chang Chuang, Chi-Hone Lien, Yi-Chih Chen, Chun-Ying Lai, Cheng-Ping Yu and Ren-Jun Hsu
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Chien-Yu Lin: Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu city 300, Taiwan
Kuo-Sen Tseng: Division of Rheumatology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
Jui-Ming Liu: Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
Heng-Chang Chuang: Division of Urology, Department of Surgery, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
Chi-Hone Lien: Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu city 300, Taiwan
Yi-Chih Chen: Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu city 300, Taiwan
Chun-Ying Lai: Division of Gastroenterology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 330, Taiwan
Cheng-Ping Yu: Biobank Management Center of the Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Ren-Jun Hsu: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan

IJERPH, 2018, vol. 15, issue 11, 1-12

Abstract: Both periodontal disease (PD) and inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are important diseases of the alimentary tract. Microbiome and immune-mediated inflammatory processes play important roles in these diseases. An association between PD and IBD may exist. This study investigated the risk of IBD in patients with PD. This study used data from the National Health Insurance Research Database of Taiwan from 1996 to 2013. A total of 27,041 patients with PD were enrolled as a study group, and 108,149 patients without PD were selected as the control group after matching by gender, age, insured region, urbanization, and income with a 1:4 ratio. Cox proportional hazards regression was used to calculate the risk of IBD. Of the 135,190 participants enrolled in this study, 5392 (4%) with newly diagnosed IBD were identified. The overall incidence of subsequent IBD was similar in both groups (3.8% vs. 4%, adjusted hazard ratio (aHR) = 1.01, 95% confidence interval (CI): 0.94–1.08). However, an increased risk of UC in the PD group was found after adjusting confounding factors (aHR: 1.56, 95% CI: 1.13–2.15; p < 0.05). This study demonstrated that patients with PD had approximately one-half higher risk of subsequent UC. Further studies are warranted to elucidate the relationship between PD and UC.

Keywords: Crohn’s disease; inflammatory bowel disease; periodontal disease; ulcerative colitis; nationwide; national health insurance research database (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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