Effect of a Toothpaste/Mouthwash Containing Carica papaya Leaf Extract on Interdental Gingival Bleeding: A Randomized Controlled Trial

Ina Saliasi, Juan Carlos Llodra, Manuel Bravo, Paul Tramini, Claude Dussart, Stéphane Viennot and Florence Carrouel
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Ina Saliasi: Laboratory “Systemic Health Care”, EA4129, University of Lyon, 69008 Lyon, France
Juan Carlos Llodra: Department of Preventive and Community Dentistry, Faculty of Odontology, University of Granada, 18010 Granada, Spain
Manuel Bravo: Department of Preventive and Community Dentistry, Faculty of Odontology, University of Granada, 18010 Granada, Spain
Paul Tramini: Department of Public Health, Faculty of Dental Medicine, University of Montpellier, 34090 Montpellier, France
Claude Dussart: Laboratory “Systemic Health Care”, EA4129, University of Lyon, 69008 Lyon, France
Stéphane Viennot: Laboratory “Systemic Health Care”, EA4129, University of Lyon, 69008 Lyon, France
Florence Carrouel: Laboratory “Systemic Health Care”, EA4129, University of Lyon, 69008 Lyon, France

IJERPH, 2018, vol. 15, issue 12, 1-16

Abstract: Clinical research on herbal-based dentifrice +/− mouth rinse products is very limited compared with the plethora of research on conventional oral care products under normal oral hygiene conditions. The aim of this study was to determine the anti-inflammatory effects of a novel plant Carica papaya leaf extract (CPLE) on interdental bleeding in healthy subjects. In this randomized, single-blind parallel-design study, the eligible subjects were generally healthy non-smokers, aged 18–26, who exhibited healthy periodontal conditions upon study entry. The participants were equally randomized into the following four groups: CPLE dentifrice, CPLE dentifrice and mouthwash, sodium lauryl sulfate (SLS)-free enzyme-containing dentifrice and SLS-free enzyme-containing dentifrice with essential oil (EO) mouthwash. Subjects were instructed to brush their teeth twice a day without changing their other brushing habits. Interdental bleeding (BOIP) was measured from inclusion (T 0 ) until the fourth week (T 4 ) of the study. Clinical efficacy was assessed after one, two, three and four weeks of home use. The analyses compared BOIP between groups and were then restricted to participants with ≥70% and then ≥80% bleeding sites at T 0 . Pairwise comparisons between groups were performed at T 0 and T 4 , and a logistic regression identified correlates of gingival bleeding (T 4 ). Among 100 subjects (2273 interdental sites), the median percentage of bleeding sites per participant at T 0 was 65%. The bleeding sites dramatically decreased in all groups between T 0 and T 4 (relative variations from −54% to −75%, p < 0.01 for all). Gingival bleeding did not significantly differ between the CPLE dentifrice and the SLS-free dentifrice +/− EO mouthwash groups (from p = 0.05 to p = 0.86), regardless of the baseline risk level. Among the CPLE dentifrice users, fewer bleeding sites were observed when toothpaste and mouthwash were combined compared to bleeding sites in those who used toothpaste alone (21% vs. 32%, p = 0.04). CPLE dentifrice/mouthwash provides an efficacious and natural alternative to SLS-free dentifrice +/−EO-containing mouthwash when used as an adjunct to mechanical oral care to reduce interdental gingival inflammation.

Keywords: biofilm; anti-inflammatory; Carica papaya; interdental bleeding; natural dentifrice; sodium lauryl sulfate free dentifrice; mouthwash; essential oils (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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