Activity of Antioxidant Enzymes and Their Association with Lipid Profile in Mexican People without Cardiovascular Disease: An Analysis of Interactions

Susana Rivera-Mancía, Angélica Saraí Jiménez-Osorio, Omar Noel Medina-Campos, Eloísa Colín-Ramírez, Maite Vallejo, Ariadna Alcántara-Gaspar, Raúl Cartas-Rosado, Jesús Vargas-Barrón and José Pedraza-Chaverri
Additional contact information
Susana Rivera-Mancía: CONACYT—Instituto Nacional de Cardiología ‘Ignacio Chávez’, Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
Angélica Saraí Jiménez-Osorio: Laboratorio de Medicina Genómica del Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Florida, Álvaro Obregón, Ciudad de México 01030, Mexico
Omar Noel Medina-Campos: Departamento Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico
Eloísa Colín-Ramírez: CONACYT—Instituto Nacional de Cardiología ‘Ignacio Chávez’, Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
Maite Vallejo: Departamento de Investigación Sociomédica, Instituto Nacional de Cardiología ‘Ignacio Chávez’ Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
Ariadna Alcántara-Gaspar: Departamento de Investigación Sociomédica, Instituto Nacional de Cardiología ‘Ignacio Chávez’ Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
Raúl Cartas-Rosado: CONACYT—Instituto Nacional de Cardiología ‘Ignacio Chávez’, Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
Jesús Vargas-Barrón: Dirección de Investigación, Instituto Nacional de Cardiología ‘Ignacio Chávez’ Juan Badiano 1, Sección XVI, Tlalpan, Ciudad de México 14080, Mexico
José Pedraza-Chaverri: Departamento Biología, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México 04510, Mexico

IJERPH, 2018, vol. 15, issue 12, 1-15

Abstract: Dyslipidemia and oxidative stress are both considered to be factors involved in cardiovascular disease; however, the relationship between them has been little explored. In this work, we studied the association between the lipid profile and the activity of antioxidant enzymes such as paraoxonase-1 (PON1), superoxide dismutase 1 (SOD1), ceruloplasmin, and catalase, as well as total antioxidant capacity (the ferric-reducing ability of plasma (FRAP)), in 626 volunteers without cardiovascular disease. Their lipid profile was evaluated, and they were classified as having or not having high triglycerides (↑TG), high low-density cholesterol (↑LDLC), and low high-density cholesterol (↓HDLC), resulting in eight groups: Without dyslipidemia, ↑TG, ↑LDLC, ↓HDLC, ↑TG↑LDLC, ↑TG↓HDLC, ↑LDLC↓HDLC, and ↑TG↑LDLC↓HDLC. When comparisons by group were made, no significant differences in the activity of antioxidant enzymes were obtained. However, the linear regression analysis considering the potential interactions between ↑TG, ↑LDLC, and ↓HDLC suggested a triple interaction between the three lipid profile alterations on the activity of PON1 and a double interaction between ↑TG and ↑LDLC on ferroxidase-ceruloplasmin activity. The analysis presented in this work showed an association between the lipid profile and antioxidant-enzyme activity and highlighted the importance of considering the interactions between the components of a phenomenon instead of studying them individually. Longitudinal studies are needed to elucidate the nature of these associations.

Keywords: dyslipidemia; cardiovascular risk; antioxidant activity; paraoxonase; superoxide dismutase; ceruloplasmin; catalase; ferric-reducing ability of plasma (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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