Statins and Cardiovascular Disease Outcomes in Chronic Kidney Disease: Reaffirmation vs. Repudiation

Chamberlain I. Obialo, Elizabeth O. Ofili and Keith C. Norris
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Chamberlain I. Obialo: Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA
Elizabeth O. Ofili: Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310-1495, USA
Keith C. Norris: Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA

IJERPH, 2018, vol. 15, issue 12, 1-7

Abstract: Cardiovascular disease (CVD) burden is several-fold higher in patients with chronic kidney disease (CKD). Although statins have been shown to provide significant CVD benefits in both the general population and patients with CKD, this has not translated into survival advantage in patients with advanced CKD or on dialysis. It has been reported that CVD risk continues to escalate as CKD progresses to end-stage kidney disease (ESKD); however, the CVD risk reduction by statins appears to decline as patients’ progress from the early to later stages of CKD. Statins have also been associated with a higher incidence of stroke in ESKD patients. Thus, the CVD benefits of statins in ESKD remain questionable.

Keywords: Statins; chronic kidney disease; cardiovascular disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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