Preventive Effect of Residential Green Space on Infantile Atopic Dermatitis Associated with Prenatal Air Pollution Exposure

Ji-Young Lee, Dirga Kumar Lamichhane, Myeongjee Lee, Shinhee Ye, Jung-Hyun Kwon, Myung-Sook Park, Hwan-Cheol Kim, Jong-Han Leem, Yun-Chul Hong, Yangho Kim, Mina Ha and Eunhee Ha
Additional contact information
Ji-Young Lee: Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 03760, Korea
Dirga Kumar Lamichhane: Department of Occupational and Environmental Medicine, School of Medicine, Inha University, Incheon 22212, Korea
Myeongjee Lee: Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 03760, Korea
Shinhee Ye: Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 03760, Korea
Jung-Hyun Kwon: Department of Pediatrics, College of Medicine, Korea University, Seoul 02841, Korea
Myung-Sook Park: Taean Environmental Health Center, Taean 32144, Korea
Hwan-Cheol Kim: Department of Occupational and Environmental Medicine, School of Medicine, Inha University, Incheon 22212, Korea
Jong-Han Leem: Department of Occupational and Environmental Medicine, School of Medicine, Inha University, Incheon 22212, Korea
Yun-Chul Hong: Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 02841, Korea
Yangho Kim: Department of Occupational and Environmental Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 44033, Korea
Mina Ha: Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan 31116, Korea
Eunhee Ha: Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 03760, Korea

IJERPH, 2018, vol. 15, issue 1, 1-11

Abstract: Few birth cohort studies have examined the role of traffic-related air pollution (TRAP) in the development of infantile atopic dermatitis (AD), but none have investigated the role of preventive factors such as green spaces. The aim of this study was to investigate whether exposure to nitrogen dioxide (NO 2 ) and particulate matter with an aerodynamic diameter of <10 μm (PM 10 ) during pregnancy is associated with increased risk of development of AD in 6-month-old children and also to examine how this association changes with residential green space. This study used prospective data from 659 participants of the Mothers and Children’s Environmental Health study. Subjects were geocoded to their residential addresses and matched with air pollution data modeled using land-use regression. Information on infantile AD was obtained by using a questionnaire administered to the parents or guardians of the children. The association between infantile AD and exposure to NO 2 and PM 10 was determined using logistic regression models. We assessed the effects of residential green spaces using stratified analyses and by entering product terms into the logistic regression models. The risk of infantile AD significantly increased with an increase in air pollution exposure during the first trimester of pregnancy. The adjusted odds ratio (OR) and 95% confidence interval (CI) were 1.219 (1.023–1.452) per 10 μg/m 3 increase in PM 10 and 1.353 (1.027–1.782) per 10 ppb increase in NO 2 . An increase in the green space within 200 m of residence was associated with a decreased risk of AD (OR = 0.996, 95% CI: 0.993–0.999). The stratified analysis of residential green space revealed stronger associations between infantile AD and PM 10 and NO 2 exposure during the first trimester in the areas in the lower tertiles of green space. This study indicated that exposure to TRAP during the first trimester of pregnancy is associated with infantile AD. Less residential green space may intensify the association between TRAP exposure and infantile AD.

Keywords: child health; atopic dermatitis; greenness; traffic-related air pollution; particulate matter; birth cohort (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.mdpi.com/1660-4601/15/1/102/pdf (application/pdf)
https://www.mdpi.com/1660-4601/15/1/102/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:15:y:2018:i:1:p:102-:d:126101

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().