Prevalence and Factors Associated with Fixed-Dose Combination Antiretroviral Drugs Adherence among HIV-Positive Pregnant Women on Option B Treatment in Mpumalanga Province, South Africa

Shandir Ramlagan, Karl Peltzer, Robert A. C. Ruiter, Nicole A. Barylski, Stephen M. Weiss and Sibusiso Sifunda
Additional contact information
Shandir Ramlagan: HIV/Aids, STI and TB Unit, Human Sciences Research Council, Private Bag X41, Pretoria 0001, South Africa
Karl Peltzer: HIV/Aids, STI and TB Unit, Human Sciences Research Council, Private Bag X41, Pretoria 0001, South Africa
Robert A. C. Ruiter: Department of Work & Social Psychology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Nicole A. Barylski: Miller School of Medicine, University of Miami, 1400 NW 10th Ave, Miami, FL 33136, USA
Stephen M. Weiss: Miller School of Medicine, University of Miami, 1400 NW 10th Ave, Miami, FL 33136, USA
Sibusiso Sifunda: HIV/Aids, STI and TB Unit, Human Sciences Research Council, Private Bag X41, Pretoria 0001, South Africa

IJERPH, 2018, vol. 15, issue 1, 1-12

Abstract: The possibility for all babies to be born and remain HIV-negative for the first year of life is achievable in South Africa. HIV-positive mothers’ adherence to their antiretroviral medication is one of the crucial factors to achieve this target. Cross-sectional data were collected at 12 community health centres, over 12 months (2014–2015), from 673 HIV-positive women, less than 6 months pregnant, attending antenatal care, and on Option B treatment. Adherence measures included the Adults AIDS Clinical Trials Group (AACTG) four-day measure, as well as the Visual Analog Scale (VAS) seven-day measure. Bivariate analyses and multivariate logistic regressions are presented. 78.8% of respondents were adherent on AACTG, while 68.8% reported VAS adherence. Bivariate analyses for increased adherence show significant associations with older age, less/no alcohol usage, disclosure of HIV status, higher HIV knowledge, no desire to avoid ARV side effects, low stigma, and low depression. AACTG showed a negative association with intimate partner violence. Multivariable logistic regression on AACTG and VAS adherence rates resulted in unique contributions to increased adherence of older age, less/no alcohol usage, higher HIV knowledge, lack of depression, and non-disclosure. Programs targeting closer side effect monitoring, HIV disclosure, pre-natal depression, alcohol intake, and HIV knowledge need consideration.

Keywords: HIV/AIDS; pregnant; ARVs; adherence; Option B (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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