Sodium Dodecyl Sulphate-Supported Nanocomposite as Drug Carrier System for Controlled Delivery of Ondansetron

Gaurav Sharma, Mu. Naushad, Bharti Thakur, Amit Kumar, Poonam Negi, Reena Saini, Anterpreet Chahal, Ashok Kumar, Florian J. Stadler and U.M.H. Aqil
Additional contact information
Gaurav Sharma: Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Mu. Naushad: Department of Chemistry, College of Science, Bld.#5, King Saud University, Riyadh 11451, Saudi Arabia
Bharti Thakur: School of Chemistry, Shoolini University, Solan 173212, India
Amit Kumar: Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
Poonam Negi: School of Pharmaceutical Sciences, Shoolini University, Solan 173212, India
Reena Saini: School of Applied Science and Biotechnology, Shoolini University, Solan 173212, India
Anterpreet Chahal: School of Applied Science and Biotechnology, Shoolini University, Solan 173212, India
Ashok Kumar: Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan 173234, India
Florian J. Stadler: Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety Evaluation, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China
U.M.H. Aqil: School of Public Health, 3rd Floor, SRM Medical College and Research, Centre, Kattankulathur 603211, India

IJERPH, 2018, vol. 15, issue 3, 1-13

Abstract: Sodium dodecyl sulphate-supported iron silicophosphate (SDS/FeSP) nanocomposite was successfully fabricated by the co-precipitation method. The SDS/FeSP nanocomposite was investigated as a drug carrier for ondansetron. The cumulative drug release of ondansetron was observed at various pH values for different time intervals, i.e., from 20 min to 48 h. A ranking of the drug release was observed at different pHs; pH 2.2 > saline (pH 5.5) > pH 7.4 > pH 9.4 > distilled water. Maximum release of encapsulated drug was found to be about 45.38% at pH 2.2. The cell viability tests of SDS/FeSP nanocomposite concluded that SDS/FeSP nanocomposite was non-cytotoxic in nature.

Keywords: sodium dodecyl sulphate; nanocomposite; drug delivery; ondansetron (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/15/3/414/pdf (application/pdf)
https://www.mdpi.com/1660-4601/15/3/414/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:15:y:2018:i:3:p:414-:d:133778

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().