Antibacterial Activity of Orthodontic Cement Containing Quaternary Ammonium Polyethylenimine Nanoparticles Adjacent to Orthodontic Brackets

Eldad Sharon, Revital Sharabi, Adi Eden, Asher Zabrovsky, Gilad Ben-Gal, Esi Sharon, Yoav Pietrokovski, Yael Houri-Haddad and Nurit Beyth
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Eldad Sharon: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Revital Sharabi: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Adi Eden: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Asher Zabrovsky: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Gilad Ben-Gal: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Esi Sharon: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Yoav Pietrokovski: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Yael Houri-Haddad: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel
Nurit Beyth: Department of Prosthodontics, Hebrew University-Hadassah, Faculty of Dental Medicine, Jerusalem 91120, Israel

IJERPH, 2018, vol. 15, issue 4, 1-8

Abstract: Enamel demineralization is a common problem found in patients using orthodontic devices, such as orthodontic braces. It was found that Streptoccocus mutans growth increases adjacent to orthodontic devices, which may result in caries development. Incorporated antibacterial quaternary ammonium polyethylenimine (QPEI) nanoparticles were previously shown to be highly efficacious against various bacteria. Combining antibacterial materials in orthodontic cement may be advantageous to prevent bacterial outgrowth adjacent to orthodontic brackets. The aim was to evaluate the efficiency of orthodontic cement containing QPEI nanoparticles in reducing S. mutans and Lactobacillus casei outgrowth adjacent to orthodontic brackets. Orthodontic brackets were bonded to the buccal surfaces of extracted lower incisors. The antibacterial effect on S. mutans and L. casei outgrowth of Neobond bracket adhesive orthodontic cement with and without QPEI nanoparticles was compared. The antibacterial effect was evaluated using crystal violet staining and bacterial count (CFU/mL). The teeth in the experimental group, with the QPEI nanoparticles cement, showed significantly lower optical density (OD) values and CFU counts of S. mutans and L. casei than the teeth in the control group ( p < 0.05). Based on the results, it can be concluded that orthodontic cement containing QPEI nanoparticles significantly inhibits S. mutans and L. casei growth around orthodontic brackets.

Keywords: antibacterial; nanoparticles; orthodontic brackets (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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