Premature Spinal Bone Loss in Women Living with HIV is Associated with Shorter Leukocyte Telomere Length

Shirin Kalyan, Neora Pick, Alice Mai, Melanie C. M. Murray, Kristen Kidson, Jackson Chu, Arianne Y. K. Albert, Hélène C. F. Côté, Evelyn J. Maan, Azita Goshtasebi, Deborah M. Money and Jerilynn C. Prior
Additional contact information
Shirin Kalyan: Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada
Neora Pick: Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
Alice Mai: Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada
Melanie C. M. Murray: Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
Kristen Kidson: Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada
Jackson Chu: Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada
Arianne Y. K. Albert: BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada
Hélène C. F. Côté: BC Women’s Health Research Institute, British Columbia Women’s Hospital, Vancouver, BC V6H 3N1, Canada
Evelyn J. Maan: Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
Azita Goshtasebi: Division of Endocrinology; Centre for Menstrual Cycle and Ovulation Research, BC Centre for the Canadian Multicentre Osteoporosis Study, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
Deborah M. Money: Oak Tree Clinic, British Columbia Women’s Hospital, Vancouver, BC, V6H 3N1, Canada
Jerilynn C. Prior: Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9 Canada

IJERPH, 2018, vol. 15, issue 5, 1-12

Abstract: With advances in combination antiretroviral therapy (cART), people living with HIV are now surviving to experience aging. Evidence suggests that individuals living with HIV are at greater risk for low bone mineral density (BMD), osteoporosis, and fractures. Better understanding of the pathophysiology of bone health in women living with HIV (WLWH) is important for treatment strategies. The goal of this study was to explore new biological factors linked to low BMD in WLWH. Standardized BMD measures of WLWH were compared to reference values from an unselected population of women from the same geographical region of the same age range. Linear regression analysis was used to assess relationships among health-related characteristics, cellular aging (measured by leukocyte telomere length; LTL), cART, and BMD of WLWH. WLWH ( n = 73; mean age 43 ± 9 years) had lower BMD Z -scores at the lumbar spine (LS) (mean difference = −0.39, p < 0.001) and total hip (TH) (−0.29, p = 0.012) relative to controls ( n = 290). WLWH between 50 and 60 years ( n = 17) had lower Z -scores at the LS ( p = 0.008) and TH ( p = 0.027) compared to controls ( n = 167). Among WLWH, LS BMD was significantly associated with LTL (R 2 = 0.09, p = 0.009) and BMI (R 2 = 0.06, p = 0.042). Spinal BMD was adversely affected in WLWH. Reduction of LTL was strongly associated with lower BMD and may relate to its pathophysiology and premature aging in WLWH.

Keywords: HIV infection; osteoporosis; women; antiretroviral therapy; leukocyte telomere length; bone mineral density (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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