Association of Insulin Resistance with Bone Strength and Bone Turnover in Menopausal Chinese-Singaporean Women without Diabetes

Maria Kalimeri, Francesca Leek, Nan Xin Wang, Huann Rong Koh, Nicole C. Roy, David Cameron-Smith, Marlena C. Kruger, Christiani Jeyakumar Henry and John J. Totman
Additional contact information
Maria Kalimeri: A*STAR-NUS Clinical Imaging Research Centre, 14 Medical Drive, Singapore 117599, Singapore
Francesca Leek: A*STAR-NUS Clinical Imaging Research Centre, 14 Medical Drive, Singapore 117599, Singapore
Nan Xin Wang: Clinical Nutrition Research Centre, 14 Medical Drive, Singapore 117599, Singapore
Huann Rong Koh: Clinical Nutrition Research Centre, 14 Medical Drive, Singapore 117599, Singapore
Nicole C. Roy: Food Nutrition & Health Team, AgResearch Grasslands, Palmerston North 4442, New Zealand
David Cameron-Smith: Food Nutrition & Health Team, AgResearch Grasslands, Palmerston North 4442, New Zealand
Marlena C. Kruger: Riddet Institute, Massey University, Palmerston North 4442, New Zealand
Christiani Jeyakumar Henry: Clinical Nutrition Research Centre, 14 Medical Drive, Singapore 117599, Singapore
John J. Totman: A*STAR-NUS Clinical Imaging Research Centre, 14 Medical Drive, Singapore 117599, Singapore

IJERPH, 2018, vol. 15, issue 5, 1-11

Abstract: Insulin resistance (IR) is accompanied by increased areal or volumetric bone mineral density (aBMD or vBMD), but also higher fracture risk. Meanwhile, imbalances in bone health biomarkers affect insulin production. This study investigates the effect of IR on proximal femur and lumbar spine BMD, femoral neck bending, compressive and impact strength indices (Composite Strength Indices) and circulating levels of parathyroid hormone (PTH), C-telopeptide of Type I collagen (CTx-1) and 25(OH) Vitamin D 3 , in a cohort of 97 healthy, non-obese, menopausal Chinese-Singaporean women. Lumbar spine aBMD was inversely associated with IR and dependent on lean body mass (LBM) and age. No such associations were found for vBMD of the third lumbar vertebra, aBMD and vBMD of the proximal femur, or circulating levels of PTH, CTx-1 and 25(OH) Vitamin D 3 . Composite Strength Indices were inversely associated with IR and independent of LBM, but after adjusting for fat mass and age, this association remained valid only for the impact strength index. Composite Strength Indices were significantly lower in participants with a high degree of IR. Our findings on IR and Composite Strength Indices relationships were in agreement with previous studies on different cohorts, but those on IR and BMD associations were not.

Keywords: insulin resistance; HOMA-IR; DXA; QCT; BMD; Composite Strength Indices; parathyroid hormone (PTH); 25(OH) Vitamin D 3; CTx-1 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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