Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population

Shih-Yi Lin, Wu-Huei Hsu, Cheng-Li Lin, Cheng-Chieh Lin, Jane-Ming Lin, Yun-Lun Chang, Chung-Y. Hsu and Chia-Hung Kao
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Shih-Yi Lin: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan
Wu-Huei Hsu: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan
Cheng-Li Lin: Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan
Cheng-Chieh Lin: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan
Jane-Ming Lin: Department of Ophthalmology, China Medical University Hospital, Taichung 40447, Taiwan
Yun-Lun Chang: Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung 40447, Taiwan
Chung-Y. Hsu: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan
Chia-Hung Kao: Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung 40402, Taiwan

IJERPH, 2018, vol. 15, issue 5, 1-12

Abstract: Direct evidence of whether thyroid cancer patients have a higher risk of age-related macular degeneration (AMD) has yet to be investigated. Patients older than 50 years-old and newly diagnosed with thyroid cancer between 2000 and 2008 were identified from the national health insurance research database (NHIRD). We applied time-varying Cox proportional hazard models to assess the association between thyroid cancer and AMD. The multivariable models included conventional cardiovascular risk factors, myopia, vitreous floaters, hypothyroidism, hyperthyroidism, and treatment modality of thyroid cancer. The analysis process was stratified by age, gender, and comorbidity. In this study, 5253 patients were included in a thyroid cancer cohort (men 24.5%; median age 59.1 years (53.7–67.4 years), and 21,012 matched controls were included in a non-thyroid cancer cohort. The AMD incidence was 40.7 per 10,000 person/year in the thyroid cancer cohort. The thyroid cancer cohort had a higher risk (adjusted hazard ratio (aHR) = 1.38, 95% confidence interval, CI = 1.09–1.75) of AMD than the non-thyroid cohort. Thyroid cancer patients had a higher risk of AMD, especially the male patients (aHR = 1.92, 95% CI = 1.38–3.14) and the patients with comorbidities (aHR = 1.38, 95% CI = 1.09–1.74). In conclusion, thyroid cancer patients older than 50 years-old have increased risk of AMD.

Keywords: thyroid cancer; age-related macular degeneration; national health insurance research database (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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