Pregnancy Trimester-Specific Exposure to Ambient Air Pollution and Child Respiratory Health Outcomes in the First 2 Years of Life: Effect Modification by Maternal Pre-Pregnancy BMI

Shu-E Soh, Anne Goh, Oon Hoe Teoh, Keith M. Godfrey, Peter D. Gluckman, Lynette Pei-Chi Shek and Yap-Seng Chong
Additional contact information
Shu-E Soh: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117549, Singapore
Anne Goh: Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore 229899, Singapore
Oon Hoe Teoh: Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore 229899, Singapore
Keith M. Godfrey: MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
Peter D. Gluckman: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117549, Singapore
Lynette Pei-Chi Shek: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117549, Singapore
Yap-Seng Chong: Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore 117549, Singapore

IJERPH, 2018, vol. 15, issue 5, 1-14

Abstract: Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1–4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study ( n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2.5 μm (PM 2.5 ) in the first trimester had an adjusted incidence rate ratio (IRR) (95% confidence interval (CI)) of 1.85 (1.23–2.78), 1.76 (1.08–2.85) and 1.90 (1.10–3.27) in quartile (Q) 2–4, with reference to Q1. This association is seen in the second trimester for bronchiolitis/bronchitis. The risk of ear infection in the first year of life was associated with exposure to PM 2.5 in the first trimester with adjusted Odds Ratio (adjOR) (95% CI) = 7.64 (1.18–49.37), 11.37 (1.47–87.97) and 8.26 (1.13–60.29) for Q2–4, and similarly in the second year with adjOR (95% CI) = 3.28 (1.00–10.73) and 4.15 (1.05–16.36) for Q2–3. Prenatal exposure to air pollution has an enhanced impact on childhood respiratory health, and differs according to maternal pre-pregnancy BMI.

Keywords: pregnancy; trimester; respiratory; air pollution; pre-pregnancy body mass index (BMI) (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/15/5/996/pdf (application/pdf)
https://www.mdpi.com/1660-4601/15/5/996/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:15:y:2018:i:5:p:996-:d:146503

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().