Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients

Lecidamia Cristina Leite Damascena, Nyellisonn Nando Nóbrega De Lucena, Isabella Lima Arrais Ribeiro, Tarciana Liberal Pereira De Araujo, Ricardo Dias De Castro, Paulo Rogério Ferreti Bonan, Eufrásio De Andrade Lima Neto, Luiz Medeiros De Araújo Filho and Ana Maria Gondim Valença
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Lecidamia Cristina Leite Damascena: Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
Nyellisonn Nando Nóbrega De Lucena: Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
Isabella Lima Arrais Ribeiro: Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
Tarciana Liberal Pereira De Araujo: Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
Ricardo Dias De Castro: Departament of Clinical and Social Dentistry, Universidade Federal da Paraíba, João Pessoa, Paraíba 50445, Brazil
Paulo Rogério Ferreti Bonan: Departament of Clinical and Social Dentistry, Universidade Federal da Paraíba, João Pessoa, Paraíba 50445, Brazil
Eufrásio De Andrade Lima Neto: Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
Luiz Medeiros De Araújo Filho: Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
Ana Maria Gondim Valença: Departament of Clinical and Social Dentistry, Universidade Federal da Paraíba, João Pessoa, Paraíba 50445, Brazil

IJERPH, 2018, vol. 15, issue 6, 1-12

Abstract: This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis ( p -value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis.

Keywords: mucositis; child; cancer (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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