Deriving A Drinking Water Guideline for A Non-Carcinogenic Contaminant: The Case of Manganese

Mathieu Valcke, Marie-Hélène Bourgault, Sami Haddad, Michèle Bouchard, Denis Gauvin and Patrick Levallois
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Mathieu Valcke: Direction de la Santé Environnementale et de la Toxicologie, Institut National de Santé Publique du Québec, 945 Avenue Wolfe, Québec, QC G1V 5B3, Canada
Marie-Hélène Bourgault: Direction de la Santé Environnementale et de la Toxicologie, Institut National de Santé Publique du Québec, 945 Avenue Wolfe, Québec, QC G1V 5B3, Canada
Sami Haddad: Department of Environmental and Occupational health, École de Santé Publique, C.P. 6128, Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada
Michèle Bouchard: Department of Environmental and Occupational health, École de Santé Publique, C.P. 6128, Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada
Denis Gauvin: Direction de la Santé Environnementale et de la Toxicologie, Institut National de Santé Publique du Québec, 945 Avenue Wolfe, Québec, QC G1V 5B3, Canada
Patrick Levallois: Direction de la Santé Environnementale et de la Toxicologie, Institut National de Santé Publique du Québec, 945 Avenue Wolfe, Québec, QC G1V 5B3, Canada

IJERPH, 2018, vol. 15, issue 6, 1-16

Abstract: Manganese is a natural contaminant of water sources. It is an essential oligo-element, which may exert toxicity at high doses, particularly via inhalation. Its toxicity by the oral route is less known, but epidemiological and experimental studies tend to support its neurodevelopmental toxicity in infants and children. This paper describes the method used by a middle-size public health institution to derive a Drinking Water Guideline (DWG) for manganese. After reviewing the work done by major public health institutions, authors confirmed the use of experimental data to derive a point-of-departure (POD) of 25 mg of manganese/kg/day, based on neurodevelopmental effects on pup rats. Then, a total uncertainty factor of 450 was applied to calculate a Toxicological Reference Value (TRV) of 55 µg/kg/day. The final DWG proposed for manganese is 60 µg/L and is based on a relative source contribution (RSC) of water of 20% and an infant drinking scenario of 182 mL/kg of body weight (BW) of water (95th percentile of the ingestion rate distribution for 0–6 months). Despite its limitations, e.g., starting with the work done by other agencies, such an approach demonstrates in a transparent way the rationale and challenging choices made by regulators when deriving a DWG.

Keywords: drinking water; inorganic manganese; health-based guideline; infants (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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