Development of a Cumulative Exposure Index (CEI) for Manganese and Comparison with Bone Manganese and Other Biomarkers of Manganese Exposure

Danelle Rolle-McFarland, Yingzi Liu, Jieqiong Zhou, Farshad Mostafaei, Yuanzhong Zhou, Yan Li, Quiyan Fan, Wei Zheng, Linda H. Nie and Ellen M. Wells
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Danelle Rolle-McFarland: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Yingzi Liu: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Jieqiong Zhou: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Farshad Mostafaei: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Yuanzhong Zhou: School of Public Health, Zunyi Medical University, Zunyi 563003, Guizhou, China
Yan Li: School of Public Health, Zunyi Medical University, Zunyi 563003, Guizhou, China
Quiyan Fan: Zunyi Medical and Pharmaceutical College, Zunyi 563003, Guizhou, China
Wei Zheng: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Linda H. Nie: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Ellen M. Wells: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA

IJERPH, 2018, vol. 15, issue 7, 1-14

Abstract: Manganese (Mn) exposure can result in parkinsonism. However, understanding of manganese neurotoxicity has been limited by the lack of a cumulative Mn biomarker. Therefore, the current goal was to develop Mn cumulative exposure indices (MnCEI), an established method to estimate cumulative exposure, and determine associations of MnCEI with blood Mn (BMn), fingernail Mn (FMn), and bone Mn (BnMn). We completed a cross-sectional study of 60 male Chinese workers. Self-reported occupational history was used to create two MnCEIs reflecting the previous 16 years (MnCEI 16 ) and total work history (MnCEI TOT ). An in vivo neutron activation analysis system was used to quantify BnMn. BMn and FMn were measured using ICP-MS. Mean (standard deviation) MnCEI TOT and MnCEI 16 were 37.5 (22.0) and 25.0 (11.3), respectively. Median (interquartile range) BMn, FMn, and BnMn were 14.1 (4.0) μg/L, 13.5 (58.5) μg/g, and 2.6 (7.2) μg/g dry bone, respectively. MnCEI 16 was significantly correlated with FMn (Spearman’s ρ = 0.44; p = 0.02), BnMn ( ρ = 0.44; p < 0.01), and MnCEI TOT ( ρ = 0.44; p < 0.01). In adjusted regression models, MnCEI 16 was significantly associated with BnMn (β = 0.03; 95% confidence interval = 0.001, 0.05); no other biomarkers were associated with MnCEI. This suggests BnMn may be a useful biomarker of the previous 16 years of Mn exposure, but larger studies are recommended.

Keywords: manganese; cumulative exposure index; biomarkers; blood manganese; fingernail manganese; bone manganese; in vivo neutron activation analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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