Exposure to Environmental Contaminants and Lung Function in Adolescents—Is There a Link?

Marike M. Leijs, Janna G. Koppe, Kees Olie, Pim De Voogt, Wim M. C. Van Aalderen and Gavin W. Ten Tusscher
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Marike M. Leijs: Department of Paediatrics and Neonatology, Emma Children’s Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands
Janna G. Koppe: Department of Paediatrics and Neonatology, Emma Children’s Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands
Kees Olie: IBED/ESPM, University of Amsterdam, 1090 GE Amsterdam, The Netherlands
Pim De Voogt: IBED/ESPM, University of Amsterdam, 1090 GE Amsterdam, The Netherlands
Wim M. C. Van Aalderen: Department of Paediatrics and Neonatology, Emma Children’s Hospital Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands
Gavin W. Ten Tusscher: Department of Paediatrics and Neonatology, Westfriesgasthuis, Maelsonstraat 3, 1624 NP Hoorn, The Netherlands

IJERPH, 2018, vol. 15, issue 7, 1-10

Abstract: Dioxins (polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDF)), polychlorinated biphenyls (PCBs), and brominated flame retardants (BDEs) are well known toxic environmental contaminants. Their possible role in the incidence of respiratory disease is not yet well understood. Previous studies showed a negative effect on lung function in relation to prenatal and lactational dioxin exposure in pre-pubertal children. Effects of BDE exposure on the lung function have not previously been evaluated. As part of a longitudinal cohort study, the effects of perinatal dioxin (PCDD/F) exposure and serum PCDD/F, dl-PCB, and BDE levels on lung function in adolescents were assessed using spirometry, a body box, and diffusion measurements. Thirty-three children (born between 1986 and 1991) consented to the current follow-up study. Prenatal, lactational, and current dioxin, PCB, and BDE concentrations were determined using GC-MS. No relationship was seen between prenatal and lactational dioxin exposure, nor with current PCB body burden, and lung function. Indications of increasing airway obstruction were seen in relation to increasing current BDE exposure. This is a novel finding and certainly warrants further research.

Keywords: dioxin; PCB; BDE; endocrine disruptors; childhood; prenatal exposure; longitudinal study; lung function (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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