2-Naphthol Levels and Allergic Disorders in Children

Tien-Jen Lin, Yueliang Leon Guo, Jiin-Chyr Hsu and I-Jen Wang
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Tien-Jen Lin: Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
Yueliang Leon Guo: National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan
Jiin-Chyr Hsu: Department of Internal Medicine, Taipei Hospital, Ministry of Health and Welfare, No. 127, Su-Yuan Road, Hsin-Chuang Dist., Taipei 242, Taiwan
I-Jen Wang: Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, No. 127, Su-Yuan Road, Hsin-Chuang Dist., Taipei 242, Taiwan

IJERPH, 2018, vol. 15, issue 7, 1-13

Abstract: Background : The measurement of polycyclic aromatic hydrocarbons (PAH) in ambient air is quite difficult to perform. Using urine biomarkers of PAH such as 2- naphthol is one approach to this problem. This study explored the association between urine 2- naphthol levels and allergic diseases. The associations between 2- naphthol levels and oxidative stress biomarkers for the possible disease pathogenesis were also investigated. Method : A total of 453 kindergarten children from the (Childhood Environment and Allergic Diseases Study) CEAS cohort with urine samples were recruited. Urine 2- naphthol levels were measured by high-performance liquid chromatography mass spectrometry (HPLC-MS/MS) and markers of oxidative stress (8OHdG) were measured by enzyme-linked immunosorbent assays (ELISA). Information on environmental risk factors and allergic diseases were also collected. The association between 2- naphthol levels, 8OHdG levels, IgE, and allergic diseases were evaluated by multivariate linear regression and logistic regression. Results : Levels of 2- naphthol were positively correlated with 8OHdG levels. A one ln-unit increase in the 2- naphthol level was positively associated to 8OHdG levels (per ln-unit: β = 100.61, p < 0.001). When dividing 2- naphthol levels into quartiles, asthma was significantly associated with 2- naphthol levels at a concentration of >1.60 ng/mL (adjusted OR: 3.14, 95% CI 1.34–7.35). Conclusion : Urine 2- naphthol levels are associated with markers of oxidative stress and the risk of allergic diseases in young children.

Keywords: naphthol; children; allergic diseases; oxidative stress (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
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