The Effects of Hydration Status on Cognitive Performances among Young Adults in Hebei, China: A Randomized Controlled Trial (RCT)

Jianfen Zhang, Na Zhang, Songming Du, Hairong He, Yifan Xu, Hao Cai, Xiaohui Guo and Guansheng Ma
Additional contact information
Jianfen Zhang: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China
Na Zhang: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China
Songming Du: Chinese Nutrition Society, 6 Guang An Men Nei Street, Xicheng District, Beijing 100053, China
Hairong He: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China
Yifan Xu: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China
Hao Cai: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China
Xiaohui Guo: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China
Guansheng Ma: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China

IJERPH, 2018, vol. 15, issue 7, 1-12

Abstract: Background : Dehydration may affect cognitive performances as water accounts for 75% of brain mass. The purpose of this study is to investigate the effects of dehydration and water supplementation on cognitive performances, and to explore the changes of brain structures and functions using MRI. Methods and Analysis : A double-blinded randomized controlled trial has been designed and will be implemented among 64 college students aged 18–23 years from Baoding, China. Subjects will be asked to restrict water for 36 h. The first morning urine will be collected and urine osmolality measured. The fasting blood samples will be collected and osmolality and copeptin will be measured. Three MRI sequences, including fMRI, ASL and 3D BRAVO will be taken to observe the changes of whole brain volume, ventricular volume, BOLD response and the cortex thickness. Cognitive performances and mood will be performed with software and questionnaires, respectively. Subjects in the water supplementation groups 1, 2, 3 will drink 200, 500 and 1000 mL of water, respectively, while subjects in the no water supplementation group will not drink any water. After 90 min, urine and blood samples, MRI scans, cognitive performances and mood will be performed. One-way ANOVA will be used to study the differences among groups. Ethics and Dissemination : The study protocol has been approved by the Peking University Institutional Review Committee. Ethical approval project identification code is IRB00001052-16071. Results will be published according to the CONSORT statement and will be reported in peer-reviewed journals.

Keywords: water; dehydration; water supplementation; cognitive performances; magnetic resonance imaging (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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