Micronuclei in Exfoliated Buccal Cells of Children Living in a Cluster Area of Salento (Southern Italy) with a High Incidence of Lung Cancer: The IMP.AIR Study

Adele Idolo, Tiziana Grassi, Francesco Bagordo, Alessandra Panico, Mattia De Giorgi, Francesca Serio, Marcello Guido, Prisco Piscitelli, Giovanni De Filippis, Annamaria Raho and Antonella De Donno
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Adele Idolo: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Tiziana Grassi: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Francesco Bagordo: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Alessandra Panico: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Mattia De Giorgi: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Francesca Serio: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Marcello Guido: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
Prisco Piscitelli: Local Health Authority ASL LE, 73100 Lecce, Italy
Giovanni De Filippis: Local Health Authority ASL LE, 73100 Lecce, Italy
Annamaria Raho: Local Health Authority ASL LE, 73100 Lecce, Italy
Antonella De Donno: Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy

IJERPH, 2018, vol. 15, issue 8, 1-15

Abstract: During the years 2014–2016 the University of Salento performed the “Impact of Air Quality on Health of Residents in the Municipalities of Cutrofiano, Galatina, Sogliano Cavour, Soleto and Sternatia” (IMP.AIR) study, an epidemiological-molecular research project aiming to evaluate early DNA damage in children living in an area of Salento with high incidence of lung cancer among the male population. One hundred and twenty-two children aged 6–8 years attending primary school were enrolled and the frequency of micronucleated cells (MNC) in oral mucosa was evaluated. In addition, a questionnaire was administered to parents to obtain information about personal data, anthropometric characteristics and lifestyles (physical activity, food habits, family context) of the children and perform a multivariate analysis to detect any factors associated with MNC occurrence. Data on airborne pollutants detected in the study area were acquired by the Regional Agency for the Environmental Protection. The presence of MNC was highlighted in about 42% of children with a mean MNC frequency of 0.49‰. The frequency of MNC was associated to obesity, consumption of red or processed meat and having a mother who smokes. Moreover, the prevalence of biomarkers was higher than in another area of Salento not included in the cluster area.

Keywords: micronucleus; exfoliated buccal cells; children; Salento; IMP.AIR study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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