Prenatal Household Air Pollution Alters Cord Blood Mononuclear Cell Mitochondrial DNA Copy Number: Sex-Specific Associations

Seyram Kaali, Darby W. Jack, Rupert Delimini, Lisa Hu, Katrin Burkart, Jones Opoku-Mensah, Ashlinn Quinn, Kenneth Ayuurebobi Ae-Ngibise, Blair J. Wylie, Ellen Abrafi Boamah-Kaali, Steven Chillrud, Seth Owusu-Agyei, Patrick L. Kinney, Andrea A. Baccarelli, Kwaku Poku Asante and Alison Gladding Lee
Additional contact information
Seyram Kaali: Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
Darby W. Jack: Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA
Rupert Delimini: Department of Biomedical Sciences, University of Health and Allied Sciences, P.O. Box 31, Ho, Ghana
Lisa Hu: Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA
Katrin Burkart: Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA
Jones Opoku-Mensah: Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
Ashlinn Quinn: Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
Kenneth Ayuurebobi Ae-Ngibise: Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
Blair J. Wylie: Division of Maternal–fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ellen Abrafi Boamah-Kaali: Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
Steven Chillrud: Lamont-Doherty Earth Observatory at Columbia University, Palisades, NY 10964, USA
Seth Owusu-Agyei: Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
Patrick L. Kinney: Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA
Andrea A. Baccarelli: Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA
Kwaku Poku Asante: Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, P. O. Box 200, Kintampo Ghana
Alison Gladding Lee: Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

IJERPH, 2018, vol. 16, issue 1, 1-12

Abstract: Background: Associations between prenatal household air pollution (HAP) exposure or cookstove intervention to reduce HAP and cord blood mononuclear cell (CBMC) mitochondrial deoxyribonucleic acid copy number (mtDNAcn), an oxidative stress biomarker, are unknown. Materials and Methods: Pregnant women were recruited and randomized to one of two cookstove interventions, including a clean-burning liquefied petroleum gas (LPG) stove, or control. Prenatal HAP exposure was determined by serial, personal carbon monoxide (CO) measurements. CBMC mtDNAcn was measured by quantitative polymerase chain reaction. Multivariable linear regression determined associations between prenatal CO and cookstove arm on mtDNAcn. Associations between mtDNAcn and birth outcomes and effect modification by infant sex were explored. Results: LPG users had the lowest CO exposures ( p = 0.02 by ANOVA). In boys only, average prenatal CO was inversely associated with mtDNAcn (? = -14.84, SE = 6.41, p = 0.03, per 1ppm increase in CO). When examined by study arm, LPG cookstove had the opposite effect in all children (LPG ? = 19.34, SE = 9.72, p = 0.049), but especially boys (? = 30.65, SE = 14.46, p = 0.04), as compared to Control. Increased mtDNAcn was associated with improved birth outcomes. Conclusions: Increased prenatal HAP exposure reduces CBMC mtDNAcn, suggesting cumulative prenatal oxidative stress injury. An LPG stove intervention may reverse this effect. Boys appear most susceptible.

Keywords: household air pollution; oxidative stress; mitochondrial DNA copy number; sex-specific effects; fetal programming (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2018
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/16/1/26/pdf (application/pdf)
https://www.mdpi.com/1660-4601/16/1/26/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:16:y:2018:i:1:p:26-:d:192630

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().