Malaria and Hantavirus Pulmonary Syndrome in Gold Mining in the Amazon Region, Brazil

Ana Cláudia Pereira Terças-Trettel, Elaine Cristina de Oliveira, Cor Jesus Fernandes Fontes, Alba Valéria Gomes de Melo, Renata Carvalho de Oliveira, Alexandro Guterres, Jorlan Fernandes, Raphael Gomes da Silva, Marina Atanaka, Mariano Martinez Espinosa and Elba Regina Sampaio de Lemos
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Ana Cláudia Pereira Terças-Trettel: Nursing Department, Mato Grosso State University Campus Tangará da Serra, Tangara da Serra (MT) 78300-000, Brazil
Elaine Cristina de Oliveira: Epidemiology Department, Health Secretary of State of Mato Grosso, Cuiaba (MT) 78000-000, Brazil
Cor Jesus Fernandes Fontes: Department, Mato Grosso Federal University, Cuiaba (MT) 78000-000, Brazil
Alba Valéria Gomes de Melo: Epidemiology Department, Health Secretary of State of Mato Grosso, Cuiaba (MT) 78000-000, Brazil
Renata Carvalho de Oliveira: Hantaviruses and Rickettsiosis Laboratory, Oswaldo Cruz—FIOCRUZ Institute, Rio de Janeiro (RJ) 21000-000, Brazil
Alexandro Guterres: Hantaviruses and Rickettsiosis Laboratory, Oswaldo Cruz—FIOCRUZ Institute, Rio de Janeiro (RJ) 21000-000, Brazil
Jorlan Fernandes: Hantaviruses and Rickettsiosis Laboratory, Oswaldo Cruz—FIOCRUZ Institute, Rio de Janeiro (RJ) 21000-000, Brazil
Raphael Gomes da Silva: Hantaviruses and Rickettsiosis Laboratory, Oswaldo Cruz—FIOCRUZ Institute, Rio de Janeiro (RJ) 21000-000, Brazil
Marina Atanaka: Department, Mato Grosso Federal University, Cuiaba (MT) 78000-000, Brazil
Mariano Martinez Espinosa: Department, Mato Grosso Federal University, Cuiaba (MT) 78000-000, Brazil
Elba Regina Sampaio de Lemos: Hantaviruses and Rickettsiosis Laboratory, Oswaldo Cruz—FIOCRUZ Institute, Rio de Janeiro (RJ) 21000-000, Brazil

IJERPH, 2019, vol. 16, issue 10, 1-11

Abstract: People living in mining regions are exposed to numerous biological agents by several specific types of transmission mechanisms. This study is designed to describe fatal hantavirus pulmonary syndrome (HPS) cases confirmed by serology and molecular analysis, where a seroprevalence survey was conducted in the gold mining regions of the state of Mato Grosso, in the official Amazon region, Brazil. Two fatal cases of HPS were confirmed in a mining area in the Legal Amazon, where malaria is one of the most important public health problems. A molecular analysis detected the presence of the genome of the Castelo dos Sonhos virus. Out of the 112 blood samples analyzed, five were positive for Plasmodium infection (four P. falciparum and one P. vivax ), and four were seropositive for hantavirus, showing a seroprevalence of 3.57%. One of the four miners who was seroreactive for hantavirus concomitantly had P. falciparum infection, which was confirmed by thick blood smear. This manuscript highlights the importance of considering hantavirus pulmonary syndrome as a diagnostic possibility in febrile infection associated with pulmonary manifestations in mining areas where malaria cases are often identified.

Keywords: malaria; hantavirus pulmonary syndrome; infectious diseases epidemiology; differential diagnosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
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