Bisphenol A, Tobacco Smoke, and Age as Predictors of Oxidative Stress in Children and Adolescents

Roberto Bono, Valeria Bellisario, Roberta Tassinari, Giulia Squillacioti, Tilde Manetta, Massimiliano Bugiani, Enrica Migliore and Pavilio Piccioni
Additional contact information
Roberto Bono: Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
Valeria Bellisario: Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
Roberta Tassinari: Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
Giulia Squillacioti: Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
Tilde Manetta: Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy
Massimiliano Bugiani: Consultant of OMP (observatory of professional diseases) of the Turin Court Prosecutor’s Office, Turin 10100, Italy
Enrica Migliore: Cancer Epidemiology, AOU Città della Salute e della Scienza di Torino, Turin 10126, Italy
Pavilio Piccioni: Unit of Pneumology and Tisiology, National Health Service (ASL TO2), Torino 10100, Italy

IJERPH, 2019, vol. 16, issue 11, 1-10

Abstract: Objectives. The purpose of this study was to investigate bisphenol A (BPA) and its role in the induction of oxidative stress and confirm the same for tobacco smoke. Methods. A total of 223 young, healthy students (7–19 years old) were recruited in Chivasso, Italy. A spot of urine of each subject was analyzed to quantify BPA, cotinine, and 15F2t-isoprostane. Results. BPA showed a slight increase of concentration proportional with increasing age, even though the 11–14 years age group had slightly lower results, inducing a V-shape. The same trend was observed for 15F2t-isoprostane and cotinine. The result of piecewise linear robust regression shows a break point of the effect of BPA on 15F2t-isoprostane at 6 ng/mg CREA ( p < 0.001). At higher levels, 15F2t-isoprostane shows an exponential increase by more than threefold for each one-log unit of BPA. An increase of oxidative stress due to BPA was observed, but only from 6 ng/mg of CREA up. Passive tobacco smoke is also able to induce an increase in oxidative stress. Conclusion. Prevention against BPA and passive tobacco smoke represents an important tool for promoting the highest health standard.

Keywords: oxidative stress; adolescents; passive tobacco smoke; BPA; public health (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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