New Insights in Computational Methods for Pharmacovigilance: E-Synthesis, a Bayesian Framework for Causal Assessment

Francesco De Pretis and Barbara Osimani
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Francesco De Pretis: Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy
Barbara Osimani: Department of Biomedical Sciences and Public Health, Marche Polytechnic University, 60126 Ancona, Italy

IJERPH, 2019, vol. 16, issue 12, 1-19

Abstract: Today’s surge of big data coming from multiple sources is raising the stakes that pharmacovigilance has to win, making evidence synthesis a more and more robust approach in the field. In this scenario, many scholars believe that new computational methods derived from data mining will effectively enhance the detection of early warning signals for adverse drug reactions, solving the gauntlets that post-marketing surveillance requires. This article highlights the need for a philosophical approach in order to fully realize a pharmacovigilance 2.0 revolution. A state of the art on evidence synthesis is presented, followed by the illustration of E-Synthesis , a Bayesian framework for causal assessment. Computational results regarding dose-response evidence are shown at the end of this article.

Keywords: advisory committees; Bayesian epistemology; data fusion; data mining; dose-responsiveness; drug approval process; E-Synthesis; evidence synthesis; pharmacovigilance (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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